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7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane | 166896-79-3

中文名称
——
中文别名
——
英文名称
7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane
英文别名
7α-Benzyloxy-24-t-butyldimethylsilyloxy-3β-tetrahydropyranyloxy-5α-cholane;7alpha-Benzyloxy-24-t-butyldimethylsilyloxy-3betatetrahydropyranyloxy-5alpha-cholane;tert-butyl-[(4R)-4-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(oxan-2-yloxy)-7-phenylmethoxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentoxy]-dimethylsilane
7α-(Benzyloxy)-24-<(tert-butyldimethylsilyl)oxy>-3β-(tetrahydropyranyloxy)-5α-cholane化学式
CAS
166896-79-3
化学式
C42H70O4Si
mdl
——
分子量
667.101
InChiKey
NOOMDBQEBPZRJR-VUGNYTJHSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    11.19
  • 重原子数:
    47
  • 可旋转键数:
    12
  • 环数:
    6.0
  • sp3杂化的碳原子比例:
    0.86
  • 拓扑面积:
    36.9
  • 氢给体数:
    0
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Treatment of neovascularization disorders with squalamine
    申请人:Zasloff Michael
    公开号:US20060166950A1
    公开(公告)日:2006-07-27
    Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    本文描述了一种有用的氨基甾醇化合物,可用作钠/质子交换器(NHE)的抑制剂。还包括使用这种氨基甾醇化合物的方法,其中包括使用抑制多种NHE的化合物以及使用仅抑制一种特定NHE的化合物的方法。此外,还公开了有利的筛选技术和评估化合物治疗活性的测定方法。
  • Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds
    申请人:Zasloff Michael
    公开号:US20060183928A1
    公开(公告)日:2006-08-17
    Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    本文描述了一种作为钠/质子交换体(NHE)抑制剂有用的氨基固醇化合物。还包括使用这种氨基固醇化合物的方法,包括使用抑制一系列NHE的化合物以及使用仅抑制特定NHE的化合物。还披露了有利的筛选技术和评估化合物治疗活性的检测方法。
  • Method of inhibiting proliferation of cells by administering an
    申请人:Magainin Pharmaceuticals Inc.
    公开号:US05994336A1
    公开(公告)日:1999-11-30
    A method of inhibiting the proliferation of a wide variety of cells is described. This method includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. The proliferation of the following types of cells can be inhibited by this method: lymphocytes, fibroblasts, epithelial cells, smooth muscle cells, and human ovarian cancer cells.
    本文描述了一种抑制各种细胞增殖的方法。该方法包括给予以下结构的化合物的有效量:##STR1## 或其药学上可接受的盐。该方法可以抑制以下类型的细胞的增殖:淋巴细胞、成纤维细胞、上皮细胞、平滑肌细胞和人类卵巢癌细胞。
  • Method of treating a viral infection by administering a steroid compound
    申请人:Magainin Pharmaceuticals Inc.
    公开号:US05763430A1
    公开(公告)日:1998-06-09
    A method of treating a viral infection includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. This compound treats the viral infection by suppressing the growth of a viral target cell. As one specific example, this compound may be used to treat HIV infection.
    一种治疗病毒感染的方法,包括给予有效量的化合物,其具有以下结构:##STR1##或其药学上可接受的盐。该化合物通过抑制病毒靶细胞的生长来治疗病毒感染。作为一个具体的例子,该化合物可用于治疗HIV感染。
  • Aminosterol compounds useful as inhibitors of the sodium/proton
    申请人:Magainin Pharmaceuticals Inc.
    公开号:US05840936A1
    公开(公告)日:1998-11-24
    Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
    本文描述了一种有用的氨基甾醇化合物,可作为钠/质子交换器(NHE)的抑制剂。还包括使用这些氨基甾醇化合物的方法,包括使用抑制一系列NHE的化合物以及使用抑制仅一种特定NHE的化合物。还公开了有利的筛选技术和评估化合物治疗活性的测定方法。
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