5-Aethyl-4-methyl-2-phenyl-1,2,3-triazol | 91331-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Aethyl-4-methyl-2-phenyl-1,2,3-triazol
• 英文别名: 4-ethyl-5-methyl-2-phenyl-2H-[1,2,3]triazole；4-Aethyl-5-methyl-2-phenyl-2H-[1,2,3]triazol；4-Ethyl-5-methyl-2-phenyltriazole
• CAS: 91331-69-0
• 化学式: C₁₁H₁₃N₃
• 分子量: 187.244
• InChiKey: SMBDCFFWIRTSQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 锌 作用下， 生成 5-Aethyl-4-methyl-2-phenyl-1,2,3-triazol
  参考文献：
  名称：

  Ponzio, Gazzetta Chimica Italiana, 1899, vol. 29 I, p. 354

  摘要：

  DOI：

文献信息

• Phenylbenzoic Acid Derivatives, Processes for the Preparation Thereof, Pharmaceutical Compositions Comprising Them, and Therapeutic Uses Thereof
  申请人：Brunet Michel

  公开号：US20080139599A1

  公开（公告）日：2008-06-12

  Compounds of the formula (1) in which R 1 , R 2 ,X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.

  本发明涉及化合物的公式（1），其中R1，R2，X，Y和Z如描述中所定义，制备这些化合物的过程，将其用于治疗失调脂质症，动脉硬化和糖尿病的用途，以及包含它们的制药组合物。
• PYRIMIDINECARBOXAMIDES AS CXCR2 MODULATORS
  申请人：SYNTRIX BIOSYSTEMS, INC.

  公开号：US20140206647A1

  公开（公告）日：2014-07-24

  There is disclosed pyridine- and pyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include pyridine- and pyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.

  本发明公开了吡啶和嘧啶羧酰胺化合物，可用作药物治疗剂，合成过程和包括吡啶和嘧啶羧酰胺化合物的制药组合物。更具体地，本发明公开了一类CXCR2抑制剂化合物，可用于治疗各种炎症和肿瘤性疾病。
• SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20140329836A1

  公开（公告）日：2014-11-06

  This invention provides compounds of formula (I): wherein R 1 , R 2 , G, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

  本发明提供了式(I)的化合物：其中R1、R2、G、n、p和q的值如规范所述，可用作HDAC6的抑制剂。本发明还提供了包含本发明化合物的制药组合物和使用该组合物治疗增生性、炎症性、感染性、神经系统或心血管疾病或障碍的方法。
• Baltzer; v. Pechmann, Justus Liebigs Annalen der Chemie, 1891, vol. 262, p. 312
  作者：Baltzer、v. Pechmann

  DOI：——

  日期：——
• PHENYLBENZOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC USES THEREOF
  申请人：Merck Patent GmbH

  公开号：EP1836149B1

  公开（公告）日：2011-04-06