4-氯达曼丹-1-OL | 914637-94-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-氯达曼丹-1-OL
• 英文名称: 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazole-3-sulfonyl chloride
• CAS: 914637-94-8
• 化学式: C₆H₇ClN₂O₂S
• mdl: MFCD08235266
• 分子量: 206.65
• InChiKey: INKHDZOCLLUBLW-UHFFFAOYSA-N

物化性质

• 沸点：
  413.4±18.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY<br/>[FR] DÉRIVÉS DE PYRROLIDINE, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, ET LEUR UTILISATION EN THÉRAPIE
  申请人：ABBVIE DEUTSCHLAND

  公开号：WO2014140310A1

  公开（公告）日：2014-09-18

  The present invention relates to pyrrolidine derivatives of formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.

  本发明涉及式(I)的吡咯烷衍生物，或其生理耐受盐。该发明涉及包含此类吡咯烷衍生物的药物组合物，以及利用此类吡咯烷衍生物进行治疗的用途。这些吡咯烷衍生物是GlyT1抑制剂。
• SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES
  申请人：ADAMED SP. Z O.O

  公开号：US20150051257A1

  公开（公告）日：2015-02-19

  Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted; or 9- or 10-membered bicyclic group, linked to —(O) x —(CH2) y — through one of its aromatic carbon atoms, consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5- or 6-membered non-aromatic heterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C 1 -C 3 -alkyls; D represents a group selected from: phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted; thiophene unsubstituted or substituted; bicyclic group consisting of imidazolering fused with 5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2 heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring; and bicyclic group consisting of benzene ring fused with—or 6-membered non-aromatic heterocyclic ring having 1 or 2 heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon N atoms of benzene ring; R represents H or —CH 3; x is 0 or 1; y is 2 or 3; and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents —CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.

  苯甲胺的磺胺基衍生物，其化学式（I）中，A代表未取代或取代的苯基；或与—(O)x—(CH2)y—连接的9-或10-成员双环族，通过其芳香碳原子之一，由与含1或2个异原子（N和O）中独立选择的群组成的芳香环并联的苯环构成，其中此类双环族未取代或取代，或者与含1或2个O原子的5-或6-成员非芳香杂环取代或未取代，其中杂环未取代或取代为一个或多个C1-C3-烷基；D代表选自：未取代或取代的苯基；未取代或取代的萘基；未取代或取代的噻吩基；由咪唑环并联的5-成员非芳香碳环组成的双环族；由苯环并联的含1或2个异原子（N、O和S）中独立选择的群组成的5-成员杂芳环，未取代或取代，并通过苯环的一个碳原子之一与磺胺基团连接；以及由苯环并联的含1或2个异原子（N和O）中独立选择的群组成的5-或6-成员非芳香杂环取代或未取代，并通过苯环的一个碳N原子之一与磺胺基团连接；R代表H或—CH3；x为0或1；y为2或3；以及其药学上可接受的盐和溶剂合物，但如果x为0且y为2，则D为未取代或取代的萘基，且如果R代表— ，则A不是未取代或取代的苯基。这些化合物可用于治疗和/或预防中枢神经系统疾病。
• [EN] SULPHONAMIDE DERIVATIVES OF BENZYLAMINE FOR THE TREATMENT OF CNS DISEASES<br/>[FR] DÉRIVÉS DE SULFONAMIDE DE LA BENZYLAMINE POUR LE TRAITEMENT DE MALADIES DU SYSTÈME NERVEUX CENTRAL (SNC)
  申请人：ADAMED SP ZOO

  公开号：WO2013140347A1

  公开（公告）日：2013-09-26

  Sulphonamide derivatives of benzylamine of formula (I), wherein A represents phenyl unsubstituted or substituted;or 9-or 10-membered bicyclic group, linked to –(O) x - (CH 2 ) y -through one of its aromatic carbon atoms,consisting of benzene ring fused with -membered heteroaromatic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N and O, wherein such bicyclic group is unsubstituted or substituted or with 5-or 6-membered non-aromaticheterocyclic ring having 1 or 2 O atoms, wherein heterocyclic ring is unsubstituted or substituted with one or more C1 -C3 - alkyls; D represents a group selected from:phenyl unsubstituted or substituted; naphthyl unsubstituted or substituted;thiophene unsubstituted or substituted;bicyclic group consisting of imidazolering fused with5-membered non-aromatic carbocyclic ring; bicyclic group consisting of benzene ring fused with 5-membered heteroaromatic ring, having 1 or 2heteroatoms independently selected from the group consisting of N, O and S, unsubstituted or substituted and linked to sulphonamide moiety through one of carbon atoms of benzene ring;and bicyclic group consisting of benzene ring fused with -or 6-membered non-aromatic heterocyclic ring having 1 or 2heteroatoms independently selected from the group consisting of N and O, unsubstituted or substituted, and linked to sulphonamide moiety through one of carbon atoms of benzene ring;R represents H or –CH 3;x is 0 or 1;yis 2 or 3;and pharmaceutically acceptable salts and solvates thereof, with the provisos that if x is 0 and y is 2, then D is naphthyl unsubstituted or substituted with one halogen atom, and if R represents –CH 3, then A is not unsubstituted or substituted phenyl. The compounds can be used in the treatment and/or prophylaxis of central nervous system disorders.

  苯甲胺的磺胺基衍生物的化学式（I），其中A代表未取代或取代的苯基；或9-或10-成员的双环族，通过其中一个芳香碳原子连接到-(O) x - (CH 2 ) y -，由苯环与含有1个或2个杂原子（从N和O组成的组中独立选择）的-成员杂芳环融合而成，其中该双环族未取代或取代，或与含有1个或2个O原子的5-或6-成员非芳杂环取代，其中杂环未取代或取代为一个或多个C1 -C3 -烷基；D代表从中选择的一组：未取代或取代的苯基；未取代或取代的萘基；未取代或取代的噻吩基；由咪唑环融合而成的5-成员非芳碳环的双环族；由苯环融合而成的含有1个或2个杂原子（从N、O和S组成的组中独立选择）的5-成员杂芳环的双环族，未取代或取代，并通过苯环的一个碳原子与磺胺基团连接；以及由苯环融合而成的5-或6-成员非芳杂环的双环族，其中杂原子独立选择自N和O组成的组，未取代或取代，并通过苯环的一个碳原子与磺胺基团连接；R代表H或-CH 3；x为0或1；y为2或3；以及其药学上可接受的盐和溶剂化合物，但是如果x为0且y为2，则D为未取代或取代的萘基且带有一个卤原子，如果R代表-CH 3，则A不是未取代或取代的苯基。这些化合物可用于治疗和/或预防中枢神经系统疾病。
• PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：EP2970215A1

  公开（公告）日：2016-01-20
• US20140275086A1
  申请人：——

  公开号：US20140275086A1

  公开（公告）日：2014-09-18