3,5-Diethyl-1,4-dimethylpyrazol | 22905-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,5-Diethyl-1,4-dimethylpyrazol
• 英文别名: 3,5-diethyl-1,4-dimethyl-1H-pyrazole；3,5-Diethyl-1,4-dimethylpyrazole
• CAS: 22905-92-6
• 化学式: C₉H₁₆N₂
• 分子量: 152.239
• InChiKey: GAJSAMXMHYCOEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE<br/>[FR] MODULATEURS D'INDOLAMINE 2,3-DIOXYGÉNASE
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO 2) LTD

  公开号：WO2017051353A1

  公开（公告）日：2017-03-30

  Provided are compounds and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of HIV; including the prevention of the progression of AIDS and general immunosuppression.

  提供了化合物及其药用盐，它们的药物组合物，它们的制备方法，以及它们在预防和/或治疗HIV方面的使用方法；包括预防艾滋病的进展和一般免疫抑制。
• SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20150111922A1

  公开（公告）日：2015-04-23

  The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R 1 , R 2 , R 3 and R 4 are as defined in the specification, for use in the treatment or prevention of a diseases o conition mediated by a prokineticin, such as psychiatric and neurological conditions.

  本发明提供了公式（I）的化合物及其药学上可接受的盐：（I）其中m、n、W、X、Y、Z、R1、R2、R3和R4如规范中所定义，用于治疗或预防由前动力素介导的疾病或情况，例如精神和神经疾病。
• 1-SULFONYL PIPERIDINE DERIVATIVES AS MODULATORS OF PROKINETICIN RECEPTORS
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20160122317A1

  公开（公告）日：2016-05-05

  The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which m, n, W, X, Y, Z, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, compositions containing them and their use in therapy.

  本发明提供了公式（I）的化合物及其药学上可接受的盐，其中m、n、W、X、Y、Z、R1、R2、R3、R4和R5的定义见说明书，以及含有它们的组合物和它们在治疗中的应用。
• SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20170340621A1

  公开（公告）日：2017-11-30

  The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof (Formula (I)) in which m, n, W, X, Y, Z, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification for use in treating irritable bowel syndrome or inflammatory bowel disease.
• US9475795B2
  申请人：——

  公开号：US9475795B2

  公开（公告）日：2016-10-25