α-azido bromomethyl-Phe-alcohol | 474713-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-azido bromomethyl-Phe-alcohol
• 英文别名: (3S)-3-azido-1-bromo-4-phenylbutan-2-ol
• CAS: 474713-41-2
• 化学式: C₁₀H₁₂BrN₃O
• 分子量: 270.129
• InChiKey: FYUMDHQSPXRLSM-RGURZIINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  34.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  异丁胺 、 (S)-四氢呋喃基琥珀酰亚胺基碳酸酯 、 α-azido bromomethyl-Phe-alcohol 、 N-(9-fluorenylmethoxycarbonyl)-4-aminobenzenesulfonyl chloride 以3.7 mg的产率得到[(3S)-oxolan-3-yl] N-[(2S)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate
  参考文献：
  名称：

  Efficient method to prepare hydroxyethylamine-based aspartyl protease inhibitors with diverse P1 side chains

  摘要：

  An efficient procedure for the solid-phase synthesis of hydroxyethylamine-based aspartyl protease inhibitors is described. The 1,2-bromo alcohol 4 is the key intermediate and is prepared in four-steps in good overall yield from commercial available amino acids. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(02)00629-4
• 作为产物：
  描述：

  (2S)-2-azido-3-phenylpropanoic acid 在 N-甲基吗啉 、 氢氧化钾 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 1.5h， 生成 α-azido bromomethyl-Phe-alcohol
  参考文献：
  名称：

  Efficient method to prepare hydroxyethylamine-based aspartyl protease inhibitors with diverse P1 side chains

  摘要：

  An efficient procedure for the solid-phase synthesis of hydroxyethylamine-based aspartyl protease inhibitors is described. The 1,2-bromo alcohol 4 is the key intermediate and is prepared in four-steps in good overall yield from commercial available amino acids. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(02)00629-4

文献信息

• Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase
  作者：Haibin Shi、Kai Liu、Ashley Xu、Shao Q. Yao

  DOI：10.1039/b910611a

  日期：——

  A small molecule microarray (SMM) platform is developed herein, which enables high-throughput discovery of affinity-based probes (AfBPs) against γ-secretase.

  本文开发了一种小分子微阵列（SMM）平台，能够实现基于亲和力的探针（AfBPs）对γ-分泌酶的高通量发现。
• Efficient method to prepare hydroxyethylamine-based aspartyl protease inhibitors with diverse P1 side chains
  作者：Masao Chino、Masahiro Wakao、Jonathan A Ellman

  DOI：10.1016/s0040-4020(02)00629-4

  日期：2002.8

  An efficient procedure for the solid-phase synthesis of hydroxyethylamine-based aspartyl protease inhibitors is described. The 1,2-bromo alcohol 4 is the key intermediate and is prepared in four-steps in good overall yield from commercial available amino acids. (C) 2002 Published by Elsevier Science Ltd.