Me2AlNBn2 | 220961-57-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Me2AlNBn2
• 英文别名: N-benzyl-N-dimethylalumanyl-1-phenylmethanamine
• CAS: 220961-57-9
• 化学式: C₁₆H₂₀AlN
• 分子量: 253.323
• InChiKey: CXWIUDMFQHVCSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.94
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Me2AlNBn2 在 calcium sulfate 、 二异丁基氢化铝 、 对甲苯磺酸 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Short, Stereoselective Syntheses of C(1→3)-linked Disaccharides

  摘要：

  Nucleophilic additions to D-isolevoglucosenone are face selective and generate the corresponding enolates which react with 1,2:3,4-di-O-isopropylidene-alpha-D-galacto-hexodialdo-1,5-pyranose to give aldol adducts. These can be reduced stereoselectively into C(1-->3) glycosides of 1,6-anhydro-D-galacto-pyranose. (C) 1997 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10460-9
• 作为产物：
  描述：

  三甲基铝 、 二苄胺 以 further solvent(s) 为溶剂， 以56%的产率得到Me2AlNBn2
  参考文献：
  名称：

  Synthesis, characterisation and a theoretical investigation of the formation of lithium dialkylaluminium amides

  摘要：

  Reaction of the pre-formed crystalline amides [(PhCH2)(2)NLi] and [Me2AlN(CH2Ph)(2)] in the presence of pyridine results in the formation of the mixed metal complex [Me2Al{(PhCH2)(2)N}(2)Li . pyr] 1. Ab initio molecular orbital calculations indicate formation of the bimetallic product is energetically favourable. Using single crystal X-ray analysis for 1 and the pyridine solvate [{(PhCH2)(2)NLi . pyr}(2)] 7, in combination with theoretical calculations, the possible driving forces for the reaction are discussed. A major contributing factor in the stabilisation of the bimetallic compound was found to be a reduction in steric crowding in the mixed metal base compared to the homometallic dialkylaluminium amide. In addition, complex 1 shows significant benzyl to lithium interactions which contribute to the overall bonding. Such interactions are unusual in that donor solvent is present as competing complexant. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-328x(98)00954-1
• 作为试剂：
  描述：

  isolevoglucosenone 在 三乙胺 、 Me2AlNBn2 作用下， 以 正庚烷 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 1,6-Anhydro-2-O-benzyl-3-deoxy-β-D-ribo-hexopyranose
  参考文献：
  名称：

  Convergent syntheses of C(1→3)-linked disaccharides starting from isolevoglucosenone

  摘要：

  Nucleophilic addition (Nu-Mf) to isolevoglucosenone 1 generates enolates stereospecifically (exo face addition) that can be reacted with sugar-derived aldehydes to give C(1-->3)-linked disaccharide precursors with high diastereoselectivity. Limitations of the method arising from unfavorable aldolate stability can be overcome by using Et2AlI as the nucleophile. This leads to products of Baylis-Hillmann condensations. One example is presented and has led to the preparation of 2,3-anhydro-3-C-[(1S)-2,6-anhydro-D-glycero-D-gulo-heptitol-1-C-yl]-beta-D-gulo-pyranose 5. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00492-9