2-pyridin-3-yl-N-[(1-pyridin-3-ylcyclohexyl)methyl]-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide | 1104270-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-pyridin-3-yl-N-[(1-pyridin-3-ylcyclohexyl)methyl]-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
• CAS: 1104270-31-6
• 化学式: C₂₂H₂₁F₃N₄OS
• 分子量: 446.496
• InChiKey: WQSMFYBMBWYADK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  96
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES<br/>[FR] COMPOSÉS DE BENZOFURANE SUBSTITUÉS ET LEURS MÉTHODES D'UTILISATION POUR LE TRAITEMENT DE MALADIES VIRALES
  申请人：MERCK SHARP & DOHME

  公开号：WO2014205593A1

  公开（公告）日：2014-12-31

  Disclosed are compounds of formula (I) that are useful as hepatitis C virus (HCV) NSSB polymerise inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NSSB polymerise activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

  揭示了公式（I）的化合物，这些化合物可用作丙型肝炎病毒（HCV）NSSB聚合酶抑制剂，以及这些化合物的合成和用于抑制HCV NSSB聚合酶活性、治疗或预防HCV感染以及在基于细胞的系统中抑制HCV病毒复制和/或病毒产生的用途。
• 5-Membered Heterocyclic Amides And Related Compounds
  申请人：H. Lundbeck A/S

  公开号：US20150005293A1

  公开（公告）日：2015-01-01

  5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式为5-成员杂环酰胺及相关化合物：其中变量如此处所述。这些化合物是配体，可用于体内或体外调节特定受体活性，特别适用于治疗与人类、家养伴侣动物和家畜动物的病理性受体激活有关的疾病。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的该类配体的方法。
• 5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS
  申请人：Lundbeck, H., A/S

  公开号：EP2178865B1

  公开（公告）日：2015-08-19
• US9133204B2
  申请人：——

  公开号：US9133204B2

  公开（公告）日：2015-09-15
• [EN] 5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS<br/>[FR] AMIDES HETEROCYCLIQUES A 5 CHAINONS ET COMPOSES ASSOCIES
  申请人：NEUROGEN CORP

  公开号：WO2009012482A2

  公开（公告）日：2009-01-22

  5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.