1-Methyl-3-methoxymethyl-5-hydroxypyrazol | 66707-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Methyl-3-methoxymethyl-5-hydroxypyrazol
• CAS: 66707-99-1
• 化学式: C₆H₁₀N₂O₂
• 分子量: 142.158
• InChiKey: QBDNHYALNVPTFA-UHFFFAOYSA-N

物化性质

• 沸点：
  264.2±25.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.27
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.28
• 氢给体数：
  1.0
• 氢受体数：
  4.0

文献信息

• ANTICANCER DRUGS AND METHODS OF MAKING AND USING SAME
  申请人：YALE UNIVERSITY

  公开号：US20210085796A1

  公开（公告）日：2021-03-25

  The present invention provides drug modifications for improving biodistribution and/or specificity of an anticancer drug. In certain embodiments, the compound of the invention comprises a drug, a linker and a core acid. The core acid can be varied to tune the properties of the compound within the body such that the compound more selectively distributes to tumors and is, or becomes active in the cytosol.