2,4-dimethylene-glutaric acid | 858795-15-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,4-dimethylene-glutaric acid
• 英文别名: 2,4-Dimethylen-glutarsaeure；2,4-Dimethylidenepentanedioic acid
• CAS: 858795-15-0
• 化学式: C₇H₈O₄
• 分子量: 156.138
• InChiKey: HVHQOVUIWLWWNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-dimethylene-glutaric acid 在 盐酸 作用下， 生成 2,4-di(ethoxycarbonyl)-1,4-pentadiene
  参考文献：
  名称：

  Buchman; Reims; Schlatter, Journal of the American Chemical Society, 1942, vol. 64, p. 2705

  摘要：

  DOI：
• 作为产物：
  描述：

  丙二酸二乙酯 在 盐酸 作用下， 生成 2,4-dimethylene-glutaric acid
  参考文献：
  名称：

  Buchman; Reims; Schlatter, Journal of the American Chemical Society, 1942, vol. 64, p. 2705

  摘要：

  DOI：

文献信息

• [EN] A LIGHT-TRIGGERABLE NANOPARTICLE LIBRARY OF FORMULATIONS FOR THE CONTROLLED RELEASE OF RNAS<br/>[FR] BIBLIOTHÈQUE DE NANOPARTICULES DÉCLENCHABLES PAR LA LUMIÈRE DE FORMULATIONS POUR LA LIBÉRATION CONTRÔLÉE D'ARN
  申请人：UNIV DE COIMBRA

  公开号：WO2020230084A1

  公开（公告）日：2020-11-19

  The present application relates to a triggerable polymeric nanoparticle (NP) library composed by several formulations, presenting physico-chemical diversity and differential responsiveness to light. In certain applications, six formulations were more efficient (up to 500%) than commercial Lipofectamine in gene knockdown activity. These formulations had differential internalization by skin cells and the endosomal escape was rapid (minutes range) as shown by the recruitment of galectin 8. The NPs described were effective in the release of siRNA and miRNA but can also be extended to the release of mRNA and other types of RNA. Acute skin wounds treated with the top hit NP complexed with miRNA-150-5p healed faster than wounds treated with scramble miRNA. Thus, light-triggerable NPs offer a new strategy to deliver topically non-coding and coding RNAs.

  本申请涉及一种可触发的聚合物纳米颗粒（NP）库，由多种配方组成，具有物理化学多样性和对光的不同响应性。在某些应用中，六种配方的基因敲降活性比商业的脂质体高效（高达500％）。这些配方对皮肤细胞的内吞作用有差异，而内体逃逸是快速的（分钟级），如通过galectin 8的招募所示。所述的NPs在释放siRNA和miRNA方面非常有效，但也可以扩展到释放mRNA和其他类型的RNA。用miRNA-150-5p复合的最佳NP处理的急性皮肤创伤愈合速度比用随机miRNA处理的愈合速度更快。因此，可触发的光纳米颗粒提供了一种新的策略，用于递送局部非编码和编码RNA。
• Copolymer of acrylamide and polysaccharide resin as electrophoretic gel medium
  申请人：FMC Corporation

  公开号：EP0087995A1

  公开（公告）日：1983-09-07

  An electrophoresis medium comprising a copolymer of acrylamide and an ethylenically unsaturated resin formed by replacing at least some of the hydroxyl hydrogens in a polysaccharide with an ethylenically unsaturated group.

  一种电泳介质，包括丙烯酰胺和乙烯不饱和树脂的共聚物，该共聚物是用乙烯不饱和基团取代多糖中至少部分羟基形成的。
• Self-crosslinking, aqueous absorbent polymer compositions
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0708119A1

  公开（公告）日：1996-04-24

  An aqueous polymer composition comprising 10 to 50 wt% of a polymer in an aqueous medium, the polymer demonstrating a maximum absorbency capacity of at least 10 g of a 1% aqueous saline solution/g polymer and consisting essentially of 25-90 wt% (4, 5),''1% α,β-ethylenically unsaturated carboxylic acid monomer, 0-50 wt% (meth)allylsulfonic acid, crosslinking comonomer comprising 0.1-10 wt% latent crosslinking comonomer or 0.01-2 wt% active crosslinking comonomer, or both, and at least one softening monomer in a sufficient amount so that the polymer has a Tg of <140°C, the softening monomer characterized as having a homopolymer that exhibits a Tg≦35°C, the aqueous composition having a viscosity of less than about 3000 mPa and being adjusted to pH 4-7 with alkali or alkaline earth metal hydroxide. Such aqueous compositions can be applied to nonwoven and woven substrates or loose cellulosic fibers to make superabsorbent products.

  一种水性聚合物组合物，包括水性介质中 10 至 50 wt%的聚合物，该聚合物的最大吸水能力为至少 10 g 1%的生理盐水溶液/g 聚合物，主要由 25-90 wt% (4，5)，''1% α，β-乙烯基不饱和羧酸单体，0-50 wt%（甲基）烯丙基磺酸，交联共聚单体（包括 0.1-10 wt%的潜交联单体或 0.01-2 wt%的活性交联单体，或两者，以及至少一种软化单体，其用量足以使聚合物的 Tg <140°C，软化单体的特征在于其均聚物显示出 Tg≦35°C，水性组合物的粘度小于约 3000 mPa，并用碱或碱土金属氢氧化物调节至 pH 4-7。这种水性组合物可用于无纺布和编织基材或松散纤维素纤维，以制造超吸水性产品。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• High internal phase emulsion foams containing polyelectrolytes
  申请人：3M Innovative Properties Company

  公开号：US20040204510A1

  公开（公告）日：2004-10-14

  This invention relates to foams made by polymerizing high internal phase emulsions (HIPE) containing polyelectrolytes. The emulsions comprise a continuous oil phase and a co- or discontinuous aqueous phase. The resulting foams are useful as a separations medium.

  本发明涉及通过聚合含有聚电解质的高内相乳液（HIPE）而制成的泡沫。乳液由连续油相和共相或非连续水相组成。由此产生的泡沫可用作分离介质。