1-phenyl-5-o-tolyl-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole | 1338583-27-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-phenyl-5-o-tolyl-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole
• 英文别名: 5-(2-Methylphenyl)-1-phenyl-3-(trifluoromethyl)furo[2,3-c]pyrazole；5-(2-methylphenyl)-1-phenyl-3-(trifluoromethyl)furo[2,3-c]pyrazole
• CAS: 1338583-27-9
• 化学式: C₁₉H₁₃F₃N₂O
• 分子量: 342.32
• InChiKey: JZACOVHTRGSKKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  31
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-苯基-3-三氟甲基-1(H)-吡唑-5-酮 在 dirhodium tetraacetate 、 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)-ethanesulfonyl azide 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 8.0h， 生成 1-phenyl-5-o-tolyl-3-(trifluoromethyl)-1H-furo[2,3-c]pyrazole
  参考文献：
  名称：

  Facile synthesis of novel CF3-substituted ring-fused furo[2,3-c]pyrazoles through Rh2(OAc)4 catalyzed [3+2] cycloaddition of 4-diazo-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one with aromatic alkynes

  摘要：

  The Rh-2(OAc)(4) catalyzed [3+2] cycloaddition of 4-diazo-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one with aromatic alkynes was studied, and this protocol can be efficiently applied to the synthesis of the novel CF3-substituted ring-fused furo[2,3-c]pyrazoles. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.007

文献信息

• Facile synthesis of novel CF3-substituted ring-fused furo[2,3-c]pyrazoles through Rh2(OAc)4 catalyzed [3+2] cycloaddition of 4-diazo-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one with aromatic alkynes
  作者：Zhenhua Zhang、Jianwei Han、Shizheng Zhu

  DOI：10.1016/j.tet.2011.09.007

  日期：2011.11

  The Rh-2(OAc)(4) catalyzed [3+2] cycloaddition of 4-diazo-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one with aromatic alkynes was studied, and this protocol can be efficiently applied to the synthesis of the novel CF3-substituted ring-fused furo[2,3-c]pyrazoles. (C) 2011 Elsevier Ltd. All rights reserved.