4-methyl-N-[(1-pyridin-3-ylcyclohexyl)methyl]-2-pyrimidin-2-yl-1,3-thiazole-5-carboxamide | 1104273-66-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methyl-N-[(1-pyridin-3-ylcyclohexyl)methyl]-2-pyrimidin-2-yl-1,3-thiazole-5-carboxamide
• CAS: 1104273-66-6
• 化学式: C₂₁H₂₃N₅OS
• 分子量: 393.513
• InChiKey: LVBACKTXVOFXIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• QUORUM SENSING ANTAGONIST, METHOD OF PREVENTING A BIOFILM FORMATION USING THE QUORUM SENSING ANTAGONIST AND METHOD OF REDUCING A BACTERIAL CONTAMINATION USING THE QUORUM SENSING ANTAGONIST
  申请人：Yoon Je-Yong

  公开号：US20100292261A1

  公开（公告）日：2010-11-18

  In the quorum sensing antagonist blocking the communication in bacteria, the method for preventing biofilm formation using this quorum sensing antagonist and the method for reducing the bacterial contamination, the quorum sensing antagonist contains the homoserine lactone moiety and sulfanylethanoyl group, and has a similar chemical structure to that of the autoinducer which is produced by bacteria as a signal, whereby the quorum sensing antagonist can inhibit the formation of biofilm and reduce the bacterial contamination as well.

  在细菌中，通过使用群体感应拮抗剂阻断通信的方法，可以防止生物膜的形成和减少细菌污染。这种群体感应拮抗剂含有同型半胱氨酸内酯基团和磺酰乙酰基团，并且具有类似于细菌产生的信号自诱导物的化学结构，从而可以抑制生物膜的形成和减少细菌污染。
• 5-Membered Heterocyclic Amides And Related Compounds
  申请人：H. Lundbeck A/S

  公开号：US20150005293A1

  公开（公告）日：2015-01-01

  5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了公式为5-成员杂环酰胺及相关化合物：其中变量如此处所述。这些化合物是配体，可用于体内或体外调节特定受体活性，特别适用于治疗与人类、家养伴侣动物和家畜动物的病理性受体激活有关的疾病。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的该类配体的方法。
• 5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS
  申请人：Lundbeck, H., A/S

  公开号：EP2178865B1

  公开（公告）日：2015-08-19
• US8507554B2
  申请人：——

  公开号：US8507554B2

  公开（公告）日：2013-08-13
• US9133204B2
  申请人：——

  公开号：US9133204B2

  公开（公告）日：2015-09-15