1,3,5-trimethyl-1H-pyrazole-4-sulfonyl fluoride | 882670-22-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3,5-trimethyl-1H-pyrazole-4-sulfonyl fluoride
• 英文别名: Trimethyl-1H-pyrazole-4-sulfonyl fluoride；1,3,5-trimethylpyrazole-4-sulfonyl fluoride
• CAS: 882670-22-6
• 化学式: C₆H₉FN₂O₂S
• 分子量: 192.214
• InChiKey: ACICVOUJYZTOQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 5-Sulfonyl-1-Piperidinyl Substituted Indole Derivatives as 5-Ht6 Receptor Antagonists for the Treatment of Cns Disorders
  申请人：Ahmed Mahmood

  公开号：US20080318933A1

  公开（公告）日：2008-12-25

  The present invention relates to novel indole derivatives such as compounds of the formula (I): which possess antagonist potency at the 5-HT 6 receptor and the use of such compounds or pharmaceutically acceptable salts or solvates thereof in the treatment of Alzheimer's disease and other CNS disorders.

  本发明涉及新型吲哚衍生物，例如公式（I）的化合物，其具有5-HT6受体的拮抗作用，并且利用这些化合物或其药学上可接受的盐或溶剂在治疗阿尔茨海默病和其他中枢神经系统疾病方面具有用途。
• 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1814873A2

  公开（公告）日：2007-08-08
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：GLAXO GROUP LTD

  公开号：WO2006038006A2

  公开（公告）日：2006-04-13

  The present invention relates to novel indole derivatives such as compounds of the formula (I): which possess antagonist potency at the 5-HT6 receptor and the use of such compounds or pharmaceutically acceptable salts or solvates thereof in the treatment of Alzheimer's disease and other CNS disorders.