4-O-acetylbenzaldehyde oxime | 757965-23-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-O-acetylbenzaldehyde oxime
• 英文别名: 4-acetoxy-benzaldehyde-oxime；4-Acetoxy-benzaldehyd-oxim；[4-(Hydroxyiminomethyl)phenyl] acetate；[4-(hydroxyiminomethyl)phenyl] acetate
• CAS: 757965-23-4
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: BXKDNDSRVBFTNU-UHFFFAOYSA-N

物化性质

• 熔点：
  87-88 °C
• 沸点：
  284.1±23.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-O-acetylbenzaldehyde oxime 在 N-氯代丁二酰亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以82%的产率得到4-O-acetylbenzohydroximoyl chloride
  参考文献：
  名称：

  Synthesis and anti-inflammatory activity of aromatic glucosinolates

  摘要：

  Aromatic GLs are important members of the glucosinolate family of compounds because of their potential biological activity and medicinal properties. This study has shown success in the high yielding synthesis of some important aromatic GLs as well as the results of testing for anti-inflammatory properties of the synthetic GLs. 3,4-Dimethoxyphenylglucosinolate was found to be the most active anti-inflammatory of the seven glucosinolates assayed. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.07.049
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 乙醚 作用下， 生成 4-O-acetylbenzaldehyde oxime
  参考文献：
  名称：

  Brady; Dunn, Journal of the Chemical Society, 1914, vol. 105, p. 827

  摘要：

  DOI：

文献信息

• A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents
  作者：Akira Nakamura、Hodaka Kanou、Junki Tanaka、Akira Imamiya、Tomohiro Maegawa、Yasuyoshi Miki

  DOI：10.1039/c7ob02858j

  日期：——

  A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.

  由高价碘试剂介导了温和的氧化方法将醛肟转化为羧酸。该方法涵盖了广泛的功能化醛肟，并在温和条件下利用PhI（OH）OTs作为氧化剂进行。
• A new one pot method for the conversion of aldehydes into nitriles using hydroxyamine and phthalic anhydride
  作者：Eng-Chi Wang、Gow-Juin Lin

  DOI：10.1016/s0040-4039(98)00654-6

  日期：1998.6

  The aryl and alkyl aldehydes were readily converted to give the corresponding nitriles in good yields using hydroxyamine and phthalic anhydride as reagents in one pot.

  在一锅中使用羟胺和邻苯二甲酸酐作为试剂，很容易将芳基和烷基醛转化为高产率的相应腈。
• Synthesis and Mesomorphic Properties of New 3-Aryl-5-cyano-4,5-dihydroisoxazoles
  作者：V. S. Bezborodov、N. N. Kovganko、V. I. Lapanik

  DOI：10.1023/b:rujo.0000019743.40861.ce

  日期：2003.12

  New 3-aryl-5-cyano-4,5-dihydroisoxazoles possessing liquid crystalline properties were synthesized in two ways. The key stage in both procedures is 1,3-dipolar cycloaddition of nitrile oxides to acrylonitrile.
• Synthesis and anti-inflammatory activity of aromatic glucosinolates
  作者：Quan V. Vo、Craige Trenerry、Simone Rochfort、Jenny Wadeson、Carolina Leyton、Andrew B. Hughes

  DOI：10.1016/j.bmc.2013.07.049

  日期：2013.10

  Aromatic GLs are important members of the glucosinolate family of compounds because of their potential biological activity and medicinal properties. This study has shown success in the high yielding synthesis of some important aromatic GLs as well as the results of testing for anti-inflammatory properties of the synthetic GLs. 3,4-Dimethoxyphenylglucosinolate was found to be the most active anti-inflammatory of the seven glucosinolates assayed. (C) 2013 Elsevier Ltd. All rights reserved.
• Brady; Dunn, Journal of the Chemical Society, 1914, vol. 105, p. 827
  作者：Brady、Dunn

  DOI：——

  日期：——