Boc3(K-ε-K)-OSu | 51513-74-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc3(K-ε-K)-OSu
• 英文别名: Epsilon Dipeptide；(2,5-dioxopyrrolidin-1-yl) (2S)-6-[[(2S)-2,6-bis[(2-methylpropan-2-yl)oxycarbonylamino]hexanoyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate
• CAS: 51513-74-7
• 化学式: C₃₁H₅₃N₅O₁₁
• 分子量: 671.789
• InChiKey: FLTIHUPZOLFIKT-SFTDATJTSA-N

物化性质

• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  47.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  207.77
• 氢给体数：
  4.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  Boc3(K-ε-K)-OSu 在 potassium carbonate 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 生成 (S)-6-[(S)-6-((S)-2,6-Bis-tert-butoxycarbonylamino-hexanoylamino)-2-tert-butoxycarbonylamino-hexanoylamino]-2-tert-butoxycarbonylamino-hexanoic acid 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  Rational Approaches to the Design of Cationic Gemini Surfactants for Gene Delivery

  摘要：

  We report a new class of amphiphilic gemini surfactants as vehicles for gene delivery into cells, and the beginnings of a systematic structure-activity study. Preliminary results suggest that combining gemini surfactants with dioleoylphosphatidylethanolamine (DOPE) should allow the preparation of liposomes of various sizes and lipid compositions. Control of such colloidal changes could be as significant as the changes in the molecular composition of the gemini surfactants in delivering optimum gene expression in animal models.

  DOI：

  10.1021/ja005681c
• 作为产物：
  描述：

  N,N'-二叔丁氧羰基-L-赖氨酸 N-丁二酰亚胺酯 在 potassium carbonate 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 生成 Boc3(K-ε-K)-OSu
  参考文献：
  名称：

  Rational Approaches to the Design of Cationic Gemini Surfactants for Gene Delivery

  摘要：

  We report a new class of amphiphilic gemini surfactants as vehicles for gene delivery into cells, and the beginnings of a systematic structure-activity study. Preliminary results suggest that combining gemini surfactants with dioleoylphosphatidylethanolamine (DOPE) should allow the preparation of liposomes of various sizes and lipid compositions. Control of such colloidal changes could be as significant as the changes in the molecular composition of the gemini surfactants in delivering optimum gene expression in animal models.

  DOI：

  10.1021/ja005681c

文献信息

• [EN] DIAMINOACID-AMINOACID-POLYAMINE BASED GEMINI SURFACTANT COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：GLAXO GROUP LTD

  公开号：WO2003082809A1

  公开（公告）日：2003-10-09

  Diaminoacid-polyamine: peptide-based gemini compounds are disclosed. The compounds are based on diaminoacid-polyamine or diaminoacid-aminoacid-polyamine backbone with peptide groups and optionally hydrocarboxyl groups linked thereto. Uses of the diaminoacid-polyamine: peptide-based gemini compounds and methods for their production are also disclosed.

  Diaminoacid-polyamine：基于肽的双子化合物已被披露。这些化合物基于二氨基酸-多胺或二氨基酸-氨基酸-多胺骨架，带有肽基团和可选择地与之连接的烃羧基团。还披露了二氨基酸-多胺：基于肽的双子化合物的用途和它们的生产方法。