NY79N95ME2 | 2617496-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: NY79N95ME2
• 英文别名: sodium;1-[4-[4-[[3-(3,6-difluoropyridin-2-yl)-1-(4-ethoxycyclohexyl)pyrazol-4-yl]carbamoyl]-1,3-thiazol-2-yl]pyrazol-1-yl]ethyl hydrogen phosphate
• CAS: 2617496-45-2
• 化学式: C25H27F2N7NaO6PS
• 分子量: 645.6
• InChiKey: FMFDQKQUOHAXDN-UHFFFAOYSA-M

文献信息

• PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20210061798A1

  公开（公告）日：2021-03-04

  Disclosed herein are embodiments of a pyrazole compound according to formula I. Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.

  披露了根据公式I的吡唑化合物的一种实施例。还披露了包含该化合物的组合物以及制造该组合物的方法。该组合物可以包含载体，例如聚合物和/或该组合物可以是喷雾干燥的制剂。还披露了一种使用该化合物和/或组合物的方法。该化合物和/或组合物可用于抑制IRAK蛋白和/或在主体上改善、治疗和/或预防IRAK相关疾病或状况。
• Pyrazole compounds, formulations thereof, and a method for using the compounds and/or formulations
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US11370787B2

  公开（公告）日：2022-06-28

  Disclosed herein are embodiments of a pyrazole compound according to formula I. Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.

  此处披露了根据式I的吡唑化合物的实施例。还披露了包含该化合物的组合物，以及制备该组合物的方法。该组合物中可以包含载体，例如聚合物；和/ 或该组合物可以是喷雾干燥形式。另外，还披露了使用该化合物和/或组合物的方法。该化合物和/或组合物可能有助于抑制IRAK蛋白，并且和/或能改善、治疗和/或预防受试者中的IRAK相关疾病或状态。
• [EN] PYRAZOLE COMPOUNDS, FORMULATIONS THEREOF, AND A METHOD FOR USING THE COMPOUNDS AND/OR FORMULATIONS<br/>[FR] COMPOSÉS DE PYRAZOLE, FORMULATIONS DE CEUX-CI, ET PROCÉDÉ D'UTILISATION DES COMPOSÉS ET/OU DES FORMULATIONS
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2021041898A1

  公开（公告）日：2021-03-04

  Disclosed herein are embodiments of a pyrazole compound according to formula (I). Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.