(E)-2-[-3-(1,3-dihydro-4-hydroxy-7-methyl-3-oxo-6-vinylisobenzofuran-5-yl)-1-methylpropenyl]-cyclopentanecarboxylic acid | 1236560-62-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: (E)-2-[-3-(1,3-dihydro-4-hydroxy-7-methyl-3-oxo-6-vinylisobenzofuran-5-yl)-1-methylpropenyl]-cyclopentanecarboxylic acid
• 英文别名: 2-[(E)-4-(6-ethenyl-4-hydroxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)but-2-en-2-yl]cyclopentane-1-carboxylic acid
• CAS: 1236560-62-5
• 化学式: C₂₁H₂₄O₅
• 分子量: 356.419
• InChiKey: QFBQFOWMQCGIJX-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Metabolism-modulating agents and uses therefor
  申请人：Whitehead Paul Jonathan

  公开号：US20060106097A1

  公开（公告）日：2006-05-18

  The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5′ monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.
• US5444072A
  申请人：——

  公开号：US5444072A

  公开（公告）日：1995-08-22
• US5525602A
  申请人：——

  公开号：US5525602A

  公开（公告）日：1996-06-11
• US5536747A
  申请人：——

  公开号：US5536747A

  公开（公告）日：1996-07-16
• US5554612A
  申请人：——

  公开号：US5554612A

  公开（公告）日：1996-09-10