[1-(2-Chloro-4-{methylaminosulfonyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride | 241801-57-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [1-(2-Chloro-4-{methylaminosulfonyl}phenyl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride
• 英文别名: N-carbamimidoyl-1-[2-chloro-4-(methylsulfamoyl)phenyl]-5-cyclopropylpyrazole-4-carboxamide;hydrochloride
• CAS: 241801-57-0
• 化学式: C₁₅H₁₇ClN₆O₃S*ClH
• 分子量: 433.318
• InChiKey: ZIPUHWUYJUWEOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• [EN] 2,5-BIS-DIAMINE-'1,4! BENZOQUINONE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE A PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREFOR<br/>[FR] DERIVES DE BENZOQUINONE 2,5-BIS-DIAMINE-[1,4], UTILES POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER, LEURS PROCEDES DE PREPARATION ET INTERMEDIAIRES UTILISES DANS LEDIT PROCEDE
  申请人：ALMA MATER STUDIORUM

  公开号：WO2003087035A1

  公开（公告）日：2003-10-23

  2,5-bis-diamine-[1,4]benzoquinonic derivatives, having a general formula (I) have proved useful for the treatment of Alzheimer's disease; a method for preparing them and intermediates used in said method are also described. Fomula (I).

  2,5-双(二氨基)-[1,4]苯醌衍生物，具有通式（I），已被证明对治疗阿尔茨海默病有用；本文还描述了制备它们的方法和所使用的中间体。公式（I）：
• N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia
  申请人：Pfizer Inc.

  公开号：US20030149043A1

  公开（公告）日：2003-08-07

  NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

  NHE-1抑制剂，使用这种NHE-1抑制剂的方法以及含有这种NHE-1抑制剂的制药组合物。NHE-1抑制剂对于减少组织缺血引起的组织损伤是有用的。
• N- (substituted five-membered di-or triaza diunsaturated ring)carbonyl guanidine derivateives for the treatment of ischemia
  申请人：Pfizer Products Inc.

  公开号：EP1454902A1

  公开（公告）日：2004-09-08

  This invention relates to NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

  本发明涉及 NHE-1 抑制剂、使用这种 NHE-1 抑制剂的方法以及含有这种 NHE-1 抑制剂的药物组合物。NHE-1 抑制剂可用于减少组织缺血造成的组织损伤。
• N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA
  申请人：Pfizer Products Inc.

  公开号：EP1056729B1

  公开（公告）日：2004-12-29
• 2,5-BIS-DIAMINE-[1,4] BENZOQUINONE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE, A PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THEREFOR
  申请人：Alma Mater Studiorum -Universita' di Bologna

  公开号：EP1497257A1

  公开（公告）日：2005-01-19