4-{[N-(2,2-二甲基丙酰)-L-亮氨酰]氨基}丁酸 | 91147-50-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 中文名称: 4-{[N-(2,2-二甲基丙酰)-L-亮氨酰]氨基}丁酸
• 英文名称: Butanoic acid, 4-((2-((2,2-dimethyl-1-oxopropyl)amino)-4-methyl-1-oxopentyl)amino)-, (S)-
• 英文别名: 4-[[(2S)-2-(2,2-dimethylpropanoylamino)-4-methylpentanoyl]amino]butanoic acid
• CAS: 91147-50-1
• 化学式: C₁₅H₂₈N₂O₄
• 分子量: 300.39
• InChiKey: DXFCILWYVUYYQX-NSHDSACASA-N

物化性质

• 沸点：
  561.8±35.0 °C(Predicted)
• 密度：
  1.059±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF
  申请人：Kozlowski Antoni

  公开号：US20110171716A1

  公开（公告）日：2011-07-14

  Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.

  本文提供的是水溶性碳水化合物聚合物，它们在其还原端单一衍生化，因此可以在单一位置选择性地结合碳水化合物聚合物。还提供了制备和结合单一衍生化碳水化合物聚合物的方法。
• POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
  申请人：NEKTAR THERAPEUTICS

  公开号：US20160022828A1

  公开（公告）日：2016-01-28

  The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

  本发明提供了通过共价结合水溶性寡聚体进行化学修饰的肽。本发明的结合物在通过任何一种给药途径进行给药时，表现出与未附着水溶性寡聚体的肽不同的特征。
• MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE
  申请人：Kuo Mei-Chang

  公开号：US20110171312A1

  公开（公告）日：2011-07-14

  Modified therapeutic peptide compositions comprising conjugates of therapeutic peptides covalently coupled to one or more hydrophilic polymers. Optionally, the therapeutic peptide is also covalently coupled to one or more moieties having one to ten carbon atoms. Methods of making and use are also provided. The conjugates, when administered by any of a number of administration routes, exhibit characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer and/or one or moiety having one to ten carbon atoms.
• US8680263B2
  申请人：——

  公开号：US8680263B2

  公开（公告）日：2014-03-25
• US9173951B2
  申请人：——

  公开号：US9173951B2

  公开（公告）日：2015-11-03