1-(4-chlorophenyl)-5-chloropyrrole-2,4-dicarbaldehyde | 1207473-51-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(4-chlorophenyl)-5-chloropyrrole-2,4-dicarbaldehyde
• 英文别名: 5-Chloro-1-(4-chlorophenyl)pyrrole-2,4-dicarbaldehyde；5-chloro-1-(4-chlorophenyl)pyrrole-2,4-dicarbaldehyde
• CAS: 1207473-51-5
• 化学式: C₁₂H₇Cl₂NO₂
• 分子量: 268.099
• InChiKey: GTXGHDYASKEHJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(4-氯苯基)-5-氧代吡咯烷-3-羧酸 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 以 氯仿 为溶剂， 以87%的产率得到1-(4-chlorophenyl)-5-chloropyrrole-2,4-dicarbaldehyde
  参考文献：
  名称：

  A novel access to bisformylated pyrroles via decarboxylation of N-aryl-γ-lactam-carboxylic acids under Vilsmeier reaction conditions

  摘要：

  A simple methodology for the conversion of substituted N-aryl-gamma-lactam 2/3-carboxylic acids to substituted N-aryl-diformylated pyrroles has been developed. Several gamma-lactam 2/3-carboxylic acids were subjected to Vilsmeier reagent and substituted diformylated pyrroles are isolated in one-step process. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.11.005

文献信息

• A novel access to bisformylated pyrroles via decarboxylation of N-aryl-γ-lactam-carboxylic acids under Vilsmeier reaction conditions
  作者：Gopa Barman、Jayanta K. Ray

  DOI：10.1016/j.tetlet.2009.11.005

  日期：2010.1

  A simple methodology for the conversion of substituted N-aryl-gamma-lactam 2/3-carboxylic acids to substituted N-aryl-diformylated pyrroles has been developed. Several gamma-lactam 2/3-carboxylic acids were subjected to Vilsmeier reagent and substituted diformylated pyrroles are isolated in one-step process. (C) 2009 Elsevier Ltd. All rights reserved.