Fmoc-Asp(OBu-t)-N3 | 329309-06-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Asp(OBu-t)-N3
• 英文别名: tert-butyl (3S)-4-azido-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoate
• CAS: 329309-06-0
• 化学式: C₂₃H₂₄N₄O₅
• 分子量: 436.467
• InChiKey: OCMCOMMJNOOPNF-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  96.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Fmoc-Asp(OBu-t)-N3 在 N,N-二异丙基乙胺 作用下， 以 甲苯 为溶剂， 反应 0.58h， 生成 p-nitrophenyl {1-{[(9H-fluorenyl-9-ylmethoxy)carbonyl]amino}-2-[(tert-butoxy)carbonyl]ethyl}carbamate
  参考文献：
  名称：

  Synthesis of Peptidyl Ureas Using p‐Nitrophenyl‐(9‐fluorenylmethoxy Carbonylamino)methyl Carbamate Derivatives

  摘要：

  An efficient synthesis of p-nitrophenyl-(9-fluorenylmethoxy, carbonylamino) methyl carbamates using isocyanates derived from Fmoc-amino acid azides and p-nitrophenol in presence of an equimolar quantity of N-ethyldiisopropyl amine is described. All the carbamates have been isolated as crystalline solids and are fully characterized. Further, their utility for the synthesis of dipeptidyl ureas has been demonstrated.

  DOI：

  10.1081/scc-120039483
• 作为产物：
  描述：

  Fmoc-Asp(OtBu)-OCO2i-Bu 在 sodium azide 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 Fmoc-Asp(OBu-t)-N3
  参考文献：
  名称：

  Babu, Vommina V. Suresh; Ananda, Kuppanna; Vasanthakumar, Ganga-Ramu, Journal of the Chemical Society. Perkin transactions I, 2000, # 24, p. 4328 - 4331

  摘要：

  DOI：

文献信息

• Patil, Basanagoud S.; Vasanthakumar, Ganga-Ramu; Suresh Babu, Vommina V., Journal of Organic Chemistry, 2003, vol. 68, # 19, p. 7274 - 7280
  作者：Patil, Basanagoud S.、Vasanthakumar, Ganga-Ramu、Suresh Babu, Vommina V.

  DOI：——

  日期：——
• Patil, Basanagoud S.; Suresh Babu, Vommina V., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004, vol. 43, # 8, p. 1721 - 1728
  作者：Patil, Basanagoud S.、Suresh Babu, Vommina V.

  DOI：——

  日期：——
• Babu, Vommina V. Suresh; Ananda, Kuppanna; Vasanthakumar, Ganga-Ramu, Journal of the Chemical Society. Perkin transactions I, 2000, # 24, p. 4328 - 4331
  作者：Babu, Vommina V. Suresh、Ananda, Kuppanna、Vasanthakumar, Ganga-Ramu

  DOI：——

  日期：——
• Synthesis of Peptidyl Ureas Using <i>p</i>‐Nitrophenyl‐(9‐fluorenylmethoxy Carbonylamino)methyl Carbamate Derivatives
  作者：Basanagoud S. Patil、Ganga‐Ramu Vasanthakumar、Vommina V. Suresh Babu

  DOI：10.1081/scc-120039483

  日期：2004.1.1

  An efficient synthesis of p-nitrophenyl-(9-fluorenylmethoxy, carbonylamino) methyl carbamates using isocyanates derived from Fmoc-amino acid azides and p-nitrophenol in presence of an equimolar quantity of N-ethyldiisopropyl amine is described. All the carbamates have been isolated as crystalline solids and are fully characterized. Further, their utility for the synthesis of dipeptidyl ureas has been demonstrated.