4-溴-3-甲基苄胺 | 170229-98-8

• 物质功能分类: 化学试剂 - 有机试剂 - 酰胺
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-溴-3-甲基苄胺
• 中文别名: 4-溴-3-甲基苯甲酰胺
• 英文名称: 4-bromo-3-methylbenzamide
• 英文别名: 4-Bromo-3-methylbenzenecarboxamidamide
• CAS: 170229-98-8
• 化学式: C₈H₈BrNO
• 分子量: 214.062
• InChiKey: ZPFPOZMNEKPBIF-UHFFFAOYSA-N

物化性质

• 熔点：
  182-185°C
• 沸点：
  280.4±33.0 °C(Predicted)
• 密度：
  1.522±0.06 g/cm3(Predicted)
• 稳定性/保质期：

  避氧化物

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S22,S24/25
• 危险类别码：
  R22
• 海关编码：
  2924299090
• 危险性防范说明：
  P261,P301+P312,P302+P352,P304+P340,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  保存方法：应存于密闭、阴凉、干燥处。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-Bromo-3-methylbenzamide
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-Bromo-3-methylbenzamide
CAS number: 170229-98-8

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H8BrNO
Molecular weight: 214.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

用途

4-溴-3-甲基苄胺是一种胺类衍生物，可用作医药中间体。

制备

4-溴-3-甲基苄胺还可用于制备HPK1的拮抗剂。据报导，它可以一步合成，由4-溴-3-甲基苯甲酸或4-溴-3-甲基苄腈制得。

反应信息

• 作为反应物：
  描述：

  4-溴-3-甲基苄胺 在 硼烷 作用下， 以 四氢呋喃 为溶剂， 生成 4-溴-3-甲基苄胺
  参考文献：
  名称：

  Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1

  摘要：

  A series of noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at PI was investigated. While the amidrazone and the amine series displayed limited oral absorption, the amidine series demonstrated generally good oral absorption and strong antithrombotic activity; the single-digit picomolar K-i achieved from this series is among the best yet reported. The present work highlights the benzamidine compound 11f (LB30812) that exhibits excellent overall profiles of potency, oral absorption and antithrombotic efficacy. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00093-8
• 作为产物：
  描述：

  3-甲基-4-溴苯甲酸 在 ammonium hydroxide 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.2h， 生成 4-溴-3-甲基苄胺
  参考文献：
  名称：

  新型苯并氧杂硼烷作为一类新型抗疟药的合成及其构效关系

  摘要：

  设计并合成了一系列含硼的苯并氧杂硼酸化合物，用于围绕7-（HOOCCH 2 CH 2）-1,3-二氢-1-羟基-2,1-苯并氧杂硼酸的结构-活性关系研究（1），目的是发现一种新的抗疟疾治疗方法。化合物1表现出 对恶性疟原虫的最佳效价（IC 50 = 26 nM），并且具有良好的类药物特性，具有低分子量（206.00），低ClogP（0.86）和高水溶性（pH 7时为750μg/ mL） 。

  DOI：

  10.1016/j.bmcl.2010.12.034

文献信息

• Transition metal-free catalytic reduction of primary amides using an abnormal NHC based potassium complex: integrating nucleophilicity with Lewis acidic activation
  作者：Mrinal Bhunia、Sumeet Ranjan Sahoo、Arpan Das、Jasimuddin Ahmed、Sreejyothi P.、Swadhin K. Mandal

  DOI：10.1039/c9sc05953a

  日期：——

  potassium complex was used as a transition metal-free catalyst for reduction of primary amides to corresponding primary amines under ambient conditions. Only 2 mol% loading of the catalyst exhibits a broad substrate scope including aromatic, aliphatic and heterocyclic primary amides with excellent functional group tolerance. This method was applicable for reduction of chiral amides and utilized for the synthesis

  异常的基于N-杂环卡宾（aNHC）的钾络合物用作无过渡金属的催化剂，用于在环境条件下将伯酰胺还原为相应的伯胺。仅催化剂的2mol％负载显示出广泛的底物范围，包括具有优异的官能团耐受性的芳族，脂族和杂环伯酰胺。该方法适用于手性酰胺的还原，并用于克级的药学上有价值的前体的合成。在机理研究过程中，通过光谱技术分离和表征了几种中间体，并且通过单晶XRD表征了一种催化中间体。定义明确的催化剂和可分离的中间体，以及一些化学计量的原位实验 NMR实验和DFT研究帮助我们勾画出了该还原过程的机理途径，从而揭示了催化剂的双重作用，包括aNHC的亲核活化以及K离子的Lewis酸性活化。
• Primary amides to amines or nitriles: a dual role by a single catalyst
  作者：Hari S. Das、Shyamal Das、Kartick Dey、Bhagat Singh、Rahul K. Haridasan、Arpan Das、Jasimuddin Ahmed、Swadhin K. Mandal

  DOI：10.1039/c9cc05856g

  日期：——

  of various primary amides to amines (25 examples). On simple modification of the reaction conditions such as in the presence of a catalytic amount of secondary amide, the same catalyst can transform the primary amides into intermediate nitrile compounds (16 examples) in excellent yields. This is the first example where such a controlled catalytic transformation of primary amides to amines or nitriles

  我们报道了锰催化的各种伯酰胺向胺的加氢甲硅烷基化还原（25个例子）。通过简单地改变反应条件，例如在催化量的仲酰胺存在下，相同的催化剂就能以优异的收率将伯酰胺转化为中间体腈化合物（16个实例）。这是第一个实例，其中已经证明了用单一催化剂将伯酰胺控制地催化转化为胺或腈。
• Acetamides and benzamides that are useful in treating sexual dysfunction
  申请人：——

  公开号：US20040029887A1

  公开（公告）日：2004-02-12

  The present invention relates to the use of compounds of formula (I) 1 for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.

  本发明涉及使用式(I)的化合物治疗性功能障碍，以及含有式(I)化合物的组合物用于治疗性功能障碍。
• An NHC‐Stabilised Phosphinidene for Catalytic Formylation: A DFT‐Guided Approach
  作者：P. Sreejyothi、Kalishankar Bhattacharyya、Shiv Kumar、Pradip Kumar Hota、Ayan Datta、Swadhin K. Mandal

  DOI：10.1002/chem.202101202

  日期：2021.8.11

  In recent years, the applications of low-valent main group compounds have gained momentum in the field of catalysis. Owing to the accessibility of two lone pairs of electrons, NHC-stabilised phosphinidenes have been found to be excellent Lewis bases; however, they cannot yet be used as catalysts. Herein, an NHC-stabilised phosphinidene, 1,3-dimethyl-2-(phenylphosphanylidene)-2,3-dihydro-1H imidazole

  近年来，低价主族化合物在催化领域的应用得到了蓬勃发展。由于两个孤对电子的可及性，已发现 NHC 稳定的膦亚基是极好的路易斯碱；然而，它们还不能用作催化剂。在此，报道了一种 NHC 稳定的膦亚基，1,3-二甲基-2-(苯基亚膦基)-2,3-二氢-1 H咪唑 (1)，用于活化 CO 2。对 CO 2活化的仔细检查通过 DFT 计算以及本征键轨道分析的过程表明，膦亚基通过两个苯环之间的非共价 π-π 相互作用与苯基硅烷相关联，这激活了 Si-H 键，促进了氢化物转移到 CO 2分子。详细的 DFT 研究与光谱实验相结合，以了解 CO 2活化的机制及其催化还原官能化，导致一系列化学惰性伯酰胺在温和反应条件下甲酰化。
• NAPHTHYRIDINES AS INHIBITORS OF HPK1
  申请人：Genentech, Inc.

  公开号：US20180282328A1

  公开（公告）日：2018-10-04

  Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

  萘啶化合物及其作为HPK1抑制剂的用途被描述。这些化合物在治疗HPK1依赖性疾病和增强免疫反应方面很有用。还描述了抑制HPK1的方法、治疗HPK1依赖性疾病的方法、增强免疫反应的方法以及制备萘啶化合物的方法。