(S)-2-(trans-N1-((S)-1-[((S)-(methylcarbamoyl)(cyclohexyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-ene-1,2-dicarbonylamino)pentanoic acid tert-butyl ester | 925240-48-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(trans-N1-((S)-1-[((S)-(methylcarbamoyl)(cyclohexyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-ene-1,2-dicarbonylamino)pentanoic acid tert-butyl ester
• 英文别名: (S)-2-(trans-N¹-((S)-1-[((S)-(methylcarbamoyl)(cyclohexyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-ene-1,2-dicarbonylamino)pentanoic acid tert-butyl ester
• CAS: 925240-48-8
• 化学式: C₄₇H₆₃N₅O₈
• 分子量: 826.046
• InChiKey: LAQIDTSUBGVAOY-SEQANWHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.57
• 重原子数：
  60.0
• 可旋转键数：
  15.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  174.05
• 氢给体数：
  4.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  (S)-2-(trans-N1-((S)-1-[((S)-(methylcarbamoyl)(cyclohexyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-ene-1,2-dicarbonylamino)pentanoic acid tert-butyl ester 在 三乙基硅烷 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以63%的产率得到(S)-2-(trans-(N¹-((S)-1-((S)-(methylcarbamoyl)(cyclohexyl)methylcarbamoyl)-2,2-dimethylpropyl)carbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-ene-1,2-dicarbonylamino)pentanoic acid
  参考文献：
  名称：

  Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: Discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-l-hydroxyproline bioisostere

  摘要：

  Potent tetrapeptidic inhibitors of the HCV NS3 protease have been developed incorporating 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a new N-acyl-L-hydroxyproline mimic. The hydroxycyclopentene template was synthesized in eight steps from commercially available, (syn)-tetrahydrophthalic anhydride. Three different amino acids were explored in the PI-position and in the P2-position the hydroxyl group of the cyclopentene template was substituted with 7-methoxy-2-phenyl-quinolin-4-ol. The P3/P4-positions were then optimized from a set of six amino acid derivatives. All inhibitors were evaluated in an in vitro assay using the full-length NS3 protease. Several potent inhibitors were identified, the most promising exhibiting a K-i value of 1.1 nM. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.044
• 作为产物：
  描述：

  L-叔亮氨酸 在 三乙基硅烷 、 lithium hydroxide 、 三乙胺 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 33.0h， 生成 (S)-2-(trans-N1-((S)-1-[((S)-(methylcarbamoyl)(cyclohexyl)methyl)carbamoyl]-2,2-dimethylpropylcarbamoyl)-4-(7-methoxy-2-phenylquinolin-4-yloxy)cyclopent-1-ene-1,2-dicarbonylamino)pentanoic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: Discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-l-hydroxyproline bioisostere

  摘要：

  Potent tetrapeptidic inhibitors of the HCV NS3 protease have been developed incorporating 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a new N-acyl-L-hydroxyproline mimic. The hydroxycyclopentene template was synthesized in eight steps from commercially available, (syn)-tetrahydrophthalic anhydride. Three different amino acids were explored in the PI-position and in the P2-position the hydroxyl group of the cyclopentene template was substituted with 7-methoxy-2-phenyl-quinolin-4-ol. The P3/P4-positions were then optimized from a set of six amino acid derivatives. All inhibitors were evaluated in an in vitro assay using the full-length NS3 protease. Several potent inhibitors were identified, the most promising exhibiting a K-i value of 1.1 nM. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.044