1-(5-tert-butyl-2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-3-[4-(6-chloro-pyrimidin-4-yloxy)-2-fluoro-phenyl]-urea | 898537-88-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(5-tert-butyl-2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-3-[4-(6-chloro-pyrimidin-4-yloxy)-2-fluoro-phenyl]-urea
• 英文别名: 1-[5-Tert-butyl-2-(4-fluorophenyl)pyrazol-3-yl]-3-[4-(6-chloropyrimidin-4-yl)oxy-2-fluorophenyl]urea
• CAS: 898537-88-7
• 化学式: C₂₄H₂₁ClF₂N₆O₂
• 分子量: 498.92
• InChiKey: GDXPLKXGTSBBKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  94
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• DISUBSTITUTED UREAS AS KINASE INHIBITORS
  申请人：Furet Pascal

  公开号：US20090131437A1

  公开（公告）日：2009-05-21

  The invention relates to compounds of the formula (I), their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said compounds for use in the diagnostic or therapeutic treatment of warm-blooded animals, especially humans, their use in the treatment of diseases or for the manufacture of pharmaceutical formulations useful in the treatment of diseases that respond to modulation of kinase activity, methods of treatment comprising administration of said compounds to a warm-blooded animal, especially a human, and processes for the manufacture of said compounds.

  该发明涉及式(I)的化合物，其作为激酶抑制剂的用途，包括所述化合物的新药物配方，所述化合物用于诊断或治疗温血动物，特别是人类，其用于治疗疾病或用于制造对激酶活性调节产生反应的疾病治疗药物配方的用途，包括将所述化合物用于治疗温血动物，特别是人类的治疗方法，以及所述化合物的制造方法。