(4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride | 472964-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride
• 英文别名: (4'-trifluoromethoxybiphenyl-4-yl)methylamine hydrochloride；4-(4-trifluoromethoxyphenyl)benzylamine hydrochloride；({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amine hydrochloride；[4-[4-(trifluoromethoxy)phenyl]phenyl]methanamine;hydrochloride
• CAS: 472964-26-4
• 化学式: C₁₄H₁₂F₃NO*ClH
• 分子量: 303.712
• InChiKey: NRDYUXUKFMIWAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.13
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride 在 三乙酰氧基硼氢化钠 、 溶剂黄146 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 18.5h， 生成 1-methylethyl 2-{4-[{[2-[2-(2,3-difluorophenyl)ethyl]-4-oxopyrido[2,3-d]pyrimidin-1(4H)-yl]acetyl}({4'-[(trifluoromethyl)oxy]-4-biphenylyl}methyl)amino]-1-piperidinyl}-2-methylpropanoate
  参考文献：
  名称：

  Bicyclic Heteroaromatic Compounds

  摘要：

  式（I）的化合物，其中各种基团在此处定义。或其药用盐。这些化合物可用于治疗动脉粥样硬化和其他炎症性疾病。

  公开号：

  US20080090851A1
• 作为产物：
  描述：

  4'-(三氟甲氧基)-4-联苯甲腈 在 palladium(II) hydroxide/carbon 盐酸 、 氢气 作用下， 以 乙醇 为溶剂， 生成 (4′-trifluoromethoxybiphenyl-4-yl)methylammonium chloride
  参考文献：
  名称：

  Bicyclic Heteroaromatic Compounds

  摘要：

  式（I）的化合物，其中各种基团在此处定义。或其药用盐。这些化合物可用于治疗动脉粥样硬化和其他炎症性疾病。

  公开号：

  US20080090851A1

文献信息

• METHODS OF TREATMENT AND PREVENTION OF METABOLIC BONE DISEASES AND DISORDERS
  申请人：SHI Yi

  公开号：US20080280829A1

  公开（公告）日：2008-11-13

  The present invention provides compostions and methods useful for treating and preventing metabolic bone diseases and disorders by inhibition of Lp-PLA 2 . The compositions and methods are useful for treating and preventing metabolic bone diseases and disorders such as, for example osteoporosis, osteopenia and osteopenia related diseases and abnormal bone marrow.

  本发明提供了用于治疗和预防代谢性骨疾病和紊乱的组合物和方法，通过抑制Lp-PLA2。这些组合物和方法可用于治疗和预防代谢性骨疾病和紊乱，例如骨质疏松症、骨质疏松症和相关疾病以及异常骨髓。
• METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS
  申请人：SHI Yi

  公开号：US20080279846A1

  公开（公告）日：2008-11-13

  The present invention provides compostions and methods useful for treating and preventing neurodegenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia.

  本发明提供了一种用于治疗和预防神经退行性疾病和神经相关疾病的组合物和方法，通过抑制Lp-PLA2。这些组合物和方法可用于治疗和预防具有异常血脑屏障（BBB）功能的疾病和疾病，例如具有可渗透性BBB的神经退行性疾病，例如但不限于阿尔茨海默病、亨廷顿病、帕金森病和血管性痴呆症。
• PYRAZOLECARBOXAMIDE DERIVATIVE, INTERMEDIATE THEREFOR, AND PEST CONTROL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：Nihon Nohyaku Co., Ltd.

  公开号：EP1384714A1

  公开（公告）日：2004-01-28

  The present invention provides novel compounds with fungicidal and bactericidal activity as well as insecticidal and miticidal activity, which are useful for controlling hazardous biological organisms and belong to pyrazolecarboxamides represented by the following formula (I) : wherein R1 represents C1-C5 alkyl; R2 represents C1-C5 alkyl, C1-C5 haloalkyl, or the like; R3 represents hydrogen or C1-C3 alkyl; R4 represents halogen, C1-C5 alkyl or the like; m is an integer of 0 to 4; R5 represents alkyl, haloalkyl, alkoxy, haloalkoxy or the like; n represents an integer of 1 to 5; and X represents hydrogen, C1-C3 alkyl, C1-C3 alkoxy, halogen, C1-C3 haloalkoxy or nitro.

  本发明提供了一种具有杀菌、杀菌、杀虫和杀螨活性的新化合物，其对控制危险的生物有机体有用，属于由以下式子（I）表示的吡唑酰胺类化合物：其中R1代表C1-C5烷基；R2代表C1-C5烷基、C1-C5卤代烷基或类似物；R3代表氢或C1-C3烷基；R4代表卤素、C1-C5烷基或类似物；m为0到4的整数；R5代表烷基、卤代烷基、烷氧基、卤代烷氧基或类似物；n为1到5的整数；X代表氢、C1-C3烷基、C1-C3烷氧基、卤素、C1-C3卤代烷氧基或硝基。
• DERIVATIVE COMPOUND INTRODUCING BIPHENYL GROUP INTO NOVEL AMINOALKANOIC ACID AND ANTIFUNGAL PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Amtixbio Co., Ltd.

  公开号：EP3992177A1

  公开（公告）日：2022-05-04

  The present invention relates to a derivative compound in which a biphenyl group is introduced into an aminoalkanoic acid, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound of the present invention exhibits excellent antifungal and fungicidal effects. Furthermore, the compound of the present invention exhibits a synergistic effect when used in combination with a conventional antifungal agent. Furthermore, the compound of the present invention provides broad-spectrum antifungal activity against a wide range of fungal pathogens. Therefore, the compound of the present invention may be widely used in fields requiring treatment with antifungal or fungicidal agents against human pathogenic fungi and animal pathogenic fungi, and phytopathogenic fungi.

  本发明涉及一种衍生化合物，其中将联苯基引入氨基烷酸、其立体异构体或其药学上可接受的盐中。本发明的化合物表现出优异的抗真菌和杀真菌效果。此外，本发明的化合物在与传统抗真菌药物联合使用时表现出协同作用。此外，本发明的化合物对广泛的真菌病原体提供广谱抗真菌活性。因此，本发明的化合物可以广泛用于需要抗真菌或杀真菌剂治疗人类病原真菌、动物病原真菌和植物病原真菌的领域。
• Pyrazolecarboxamides, intermediates therefor and pest control agent comprising the same as active ingredients
  申请人：Okada Itaru

  公开号：US20050085524A1

  公开（公告）日：2005-04-21

  The present invention provides novel compounds with fungicidal and bactericidal activity as well as insecticidal and miticidal activity, which are useful for controlling hazardous biological organisms and belong to pyrazolecarboxamides represented by the following formula (I): wherein R 1 represents C 1 -C 5 alkyl; R 2 represents C 1 -C 5 alkyl, C 1 -C 5 haloalkyl, or the like; R 3 represents hydrogen or C 1 -C 3 alkyl; R 4 represents halogen, C 1 -C 5 alkyl or the like; n is an integer of 0 to 4; R 5 represents alkyl, haloalkyl, alkoxy, haloalkoxy or the like; n represents an integer of 1 to 5; and X represents hydrogen, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, halogen, C 1 -C 3 haloalkoxy or nitro.

  本发明提供了一种具有杀菌和杀菌活性以及杀虫和杀螨活性的新化合物，用于控制危险的生物有机体，属于以下式子（I）所代表的吡唑甲酰胺类化合物： 其中，R1代表C1-C5烷基；R2代表C1-C5烷基、C1-C5卤代烷基或类似物；R3代表氢或C1-C3烷基；R4代表卤素、C1-C5烷基或类似物；n是0到4的整数；R5代表烷基、卤代烷基、烷氧基、卤代烷氧基或类似物；n代表1到5的整数；X代表氢、C1-C3烷基、C1-C3烷氧基、卤素、C1-C3卤代烷氧基或硝基。