4-[(5-amino-1-oxopentyl)amino]butanoic acid | 90729-06-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 4-[(5-amino-1-oxopentyl)amino]butanoic acid
• 英文别名: 4-(5-aminopentanamido)butanoic acid；4-(5-Aminopentanoylamino)butanoic acid
• CAS: 90729-06-9
• 化学式: C₉H₁₈N₂O₃
• 分子量: 202.254
• InChiKey: DVNSZRRXSLTERK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Enzymatically responsive magnetic particles and their use
  申请人：BRANDEIS UNIVERSITY

  公开号：US10857243B2

  公开（公告）日：2020-12-08

  The invention relates to an enzymatically responsive product that includes an amino acid residue conjugated to a magnetic particle, wherein the amino acid residue is phosphorylated or sulfated or comprises an ester-moiety linked via peptide bond. Compositions containing the enzymatically responsive product, and the use thereof for separating distinct types of mammalian cells (e.g., cancer cells from normal cells), for treating a cancerous condition, and imaging cancer cells are also disclosed.

  本发明涉及一种酶反应产品，它包括与磁性微粒共轭的氨基酸残基，其中氨基酸残基被磷酸化或硫酸化，或包括通过肽键连接的酯基。本发明还公开了含有该酶反应产物的组合物及其在分离不同类型的哺乳动物细胞（如癌细胞与正常细胞）、治疗癌症和癌细胞成像方面的用途。
• Synthetic peptides, enzymatic formation of pericellular hydrogels/nanofibrils, and methods of use
  申请人：BRANDEIS UNIVERSITY

  公开号：US11155576B2

  公开（公告）日：2021-10-26

  Disclosed are peptides that contain up to about 35 amino acids, including a plurality of aromatic amino acid residues and either (i) an amino acid residue that is phosphorylated or sulfated, or (ii) an amino acid comprising an ester-moiety linked via peptide bond, or both (i) and (ii), wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the phosphate group, the sulfate group, or the ester-moiety. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for in vitro and in vivo cellular imaging, treating cancerous conditions, collecting a secretome from a cell upon which the pericellular hydrogels/nanofibrils form, and screening the collected secretome.

  已公开的多肽含有多达约 35 个氨基酸，包括多个芳香族氨基酸残基和 (i) 磷酸化或硫酸化的氨基酸残基，或 (ii) 包含通过肽键连接的酯基的氨基酸，或 (i) 和 (ii) 两者，其中多肽能够在水解磷酸基、硫酸基或酯基的酶存在下自组装形成纳米纤维。这些肽是酶反应性水凝胶剂，当暴露于分泌或表达具有水解酶活性的表面结合外切酶的靶细胞时，可形成细胞周水凝胶/纳米纤维。这些材料和含有这些材料的组合物可用于体外和体内细胞成像、治疗癌症、从形成细胞周水凝胶/纳米纤维的细胞中收集分泌物组，以及筛选所收集的分泌物组。
• SYNTHETIC PEPTIDES, ENZYMATIC FORMATION OF PERICELLULAR HYDROGELS/NANOFIBRILS, AND METHODS OF USE
  申请人：BRANDEIS UNIVERSITY

  公开号：US20170037082A1

  公开（公告）日：2017-02-09

  Disclosed are peptides that contain up to about 35 amino acids, including a plurality of aromatic amino acid residues and either (i) an amino acid residue that is phosphorylated or sulfated, or (ii) an amino acid comprising an ester-moiety linked via peptide bond, or both (i) and (ii), wherein the peptide is capable of self-assembly to form nanofibrils in the presence of an enzyme that hydrolyzes the phosphate group, the sulfate group, or the ester-moiety. These peptides are enzymatically responsive hydrogelators, and they can be used to form pericellular hydrogels/nanofibrils upon exposure to target cells that secrete or express a surface bound ectoenzyme having hydrolase activity suitable to induce peptide gelation. These materials, and compositions containing the same, can be used for in vitro and in vivo cellular imaging, treating cancerous conditions, collecting a secretome from a cell upon which the pericellular hydrogels/nanofibrils form, and screening the collected secretome.
• ENZYMATICALLY RESPONSIVE MAGNETIC PARTICLES AND THEIR USE
  申请人：BRANDEIS UNIVERSITY

  公开号：US20170119910A1

  公开（公告）日：2017-05-04

  The invention relates to an enzymatically responsive product that includes an amino acid residue conjugated to a magnetic particle, wherein the amino acid residue is phosphorylated or sulfated or comprises an ester-moiety linked via peptide bond. Compositions containing the enzymatically responsive product, and the use thereof for separating distinct types of mammalian cells (e.g., cancer cells from normal cells), for treating a cancerous condition, and imaging cancer cells are also disclosed.
• [EN] TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY<br/>[FR] COMPOSÉS PEPTIDOMIMÉTIQUES FIXÉS SUR UNE MATRICE ET PRÉSENTANT UNE ACTIVITÉ ANTAGONISTE DU CCR10
  申请人：POLYPHOR AG

  公开号：WO2011060832A1

  公开（公告）日：2011-05-26

  Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain are defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematological diseases and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.