4-butyl-2-(2-chloro-4-fluorophenyl)-5-[2-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | 1217365-48-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-butyl-2-(2-chloro-4-fluorophenyl)-5-[2-(morpholin-4-ylmethyl)benzyl]-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
• 英文别名: 4-butyl-2-(2-chloro-4-fluorophenyl)-5-[[2-(morpholin-4-ylmethyl)phenyl]methyl]-1H-pyrazolo[4,3-c]pyridine-3,6-dione
• CAS: 1217365-48-4
• 化学式: C₂₈H₃₀ClFN₄O₃
• 分子量: 525.023
• InChiKey: FONZIFPDKGIOAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  65.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
  申请人：GENKYO TEX SA

  公开号：EP2165707A1

  公开（公告）日：2010-03-24

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及Formula (I)的吡唑吡啶衍生物，其药物组成以及它们用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH氧化酶）相关的疾病或症状。
• PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS
  申请人：Page Patrick

  公开号：US20110178081A1

  公开（公告）日：2011-07-21

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

  本发明涉及公式（I）的吡唑吡啶衍生物，其药物组合物以及它们用于治疗和/或预防与烟酰胺腺嘌呤二核苷酸磷酸酰化酶（NADPH氧化酶）相关的疾病或症状的用途。
• US8455485B2
  申请人：——

  公开号：US8455485B2

  公开（公告）日：2013-06-04
• US9012449B2
  申请人：——

  公开号：US9012449B2

  公开（公告）日：2015-04-21
• [EN] PYRAZOLO PYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLOPYRIDINE UTILISÉS COMME INHIBITEURS DE LA NADPH OXYDASE
  申请人：GENKYOTEX SA

  公开号：WO2010035219A2

  公开（公告）日：2010-04-01

  The present invention is related to pyrazolo pyridine derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).