N-phenyl-8-nonenamide | 885664-73-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-8-nonenamide
• 英文别名: N-phenylnon-8-enamide
• CAS: 885664-73-3
• 化学式: C₁₅H₂₁NO
• 分子量: 231.338
• InChiKey: PBPJUTIRYPKFEY-UHFFFAOYSA-N

物化性质

• 沸点：
  402.2±24.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-phenyl-8-nonenamide 在 溶剂黄146 、 间氯过氧苯甲酸 、 potassium bromide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 10.0h， 生成 9-bromo-8-hydroxy-N-phenyl-nonanamide
  参考文献：
  名称：

  Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases

  摘要：

  Suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylase, is used in clinical trials for a variety of advanced cancers. Twelve new analogs of SAHA were synthesized and tested as in vitro inhibitors of isolated histone deacetylases (HDACS) and in vivo inhibitors of interferon regulated transcriptional responses (a marker for HDAC activity). The analogs containing an alpha-mercaptoketone or an alpha-thioacetoxyketone were more potent than SAHA in both assays. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.12.047
• 作为产物：
  描述：

  8-壬烯酸 、 苯胺 在 1-羟基苯并三唑 、 达卡巴嗪 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 以92%的产率得到N-phenyl-8-nonenamide
  参考文献：
  名称：

  Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases

  摘要：

  Suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylase, is used in clinical trials for a variety of advanced cancers. Twelve new analogs of SAHA were synthesized and tested as in vitro inhibitors of isolated histone deacetylases (HDACS) and in vivo inhibitors of interferon regulated transcriptional responses (a marker for HDAC activity). The analogs containing an alpha-mercaptoketone or an alpha-thioacetoxyketone were more potent than SAHA in both assays. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.12.047

文献信息

• [EN] PROSTAGLANDIN TRANSPORTER INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE TRANSPORTEUR DE PROSTAGLANDINE ET LEURS UTILISATIONS
  申请人：EINSTEIN COLL MED

  公开号：WO2011037610A1

  公开（公告）日：2011-03-31

  Disclosed are compounds for inhibiting prostaglandin transporter (PGT) activity, pharmaceuticals compositions including the compounds, and methods of treating subjects using the compounds.

  揭示了用于抑制前列腺素转运体（PGT）活性的化合物，包括这些化合物的药物组合物，以及使用这些化合物治疗受试者的方法。
• Palladium(II)-Catalyzed Enantioselective Hydrooxygenation of Unactivated Terminal Alkenes
  作者：Xintuo Yang、Xiang Li、Pinhong Chen、Guosheng Liu

  DOI：10.1021/jacs.2c02753

  日期：2022.5.11

  A novel Pd(II)-catalyzed enantioselective Markovnikov hydrooxygenation of unactivated terminal alkenes using a substituted pyridinyl oxazoline (Pyox) ligand has been developed. Herein it was discovered that the (EtO)2MeSiH/BQ redox system is vital for the highly selective and efficient hydrooxygenation, where the alkylpalladium(II) species generated from enantioselective oxypalladation step is reduced

  已经开发了一种使用取代的吡啶基恶唑啉 (Pyox) 配体对未活化末端烯烃进行新型 Pd(II) 催化的对映选择性马尔科夫尼科夫加氢氧化反应。在此发现 (EtO) 2 MeSiH/BQ 氧化还原系统对于高选择性和高效的加氢氧化至关重要，其中对映选择性氧化钯化步骤产生的烷基钯 (II) 物质被硅烷还原。该方法提供了从易于获得的烯烃中高效获得光学纯醇酯的方法，具有优异的对映选择性，并具有广泛的底物范围。