[1-(2,3-Dimethoxyphenyl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride | 241801-78-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [1-(2,3-Dimethoxyphenyl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride
• 英文别名: N-carbamimidoyl-5-cyclopropyl-1-(2,3-dimethoxyphenyl)pyrazole-4-carboxamide;hydrochloride
• CAS: 241801-78-5
• 化学式: C₁₆H₁₉N₅O₃*ClH
• 分子量: 365.819
• InChiKey: GCCKOWPGNMBLTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia
  申请人：Pfizer Inc.

  公开号：US20030149043A1

  公开（公告）日：2003-08-07

  NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

  NHE-1抑制剂，使用这种NHE-1抑制剂的方法以及含有这种NHE-1抑制剂的制药组合物。NHE-1抑制剂对于减少组织缺血引起的组织损伤是有用的。
• N- (substituted five-membered di-or triaza diunsaturated ring)carbonyl guanidine derivateives for the treatment of ischemia
  申请人：Pfizer Products Inc.

  公开号：EP1454902A1

  公开（公告）日：2004-09-08

  This invention relates to NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.

  本发明涉及 NHE-1 抑制剂、使用这种 NHE-1 抑制剂的方法以及含有这种 NHE-1 抑制剂的药物组合物。NHE-1 抑制剂可用于减少组织缺血造成的组织损伤。
• Compositions and methods for modulating interaction between polypeptides
  申请人：Kazantsev G. Aleksey

  公开号：US20050239833A1

  公开（公告）日：2005-10-27

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.

  本发明部分基于我们所进行的检测，这些检测揭示了可用于治疗或预防以一种蛋白质与另一种蛋白质的异常或不良结合为特征的疾病的化合物。
• N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA
  申请人：Pfizer Products Inc.

  公开号：EP1056729B1

  公开（公告）日：2004-12-29
• COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES
  申请人：The General Hospital Corporation

  公开号：US20130203733A1

  公开（公告）日：2013-08-08

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.