2-((3-ethoxy-4-hydroxybenzylidene)amino)-10-hydroxy-5H-phenophosphazinine 10-oxide | 1146702-36-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 2-((3-ethoxy-4-hydroxybenzylidene)amino)-10-hydroxy-5H-phenophosphazinine 10-oxide
• CAS: 1146702-36-4
• 化学式: C₂₁H₁₉N₂O₄P
• 分子量: 394.367
• InChiKey: KBGUVXRGAKATFW-UHFFFAOYSA-N

物化性质

• 熔点：
  204 °C(Solvent: Methanol)
• 沸点：
  732.7±60.0 °C(predicted)
• 密度：
  1.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.82
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  91.15
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-((3-ethoxy-4-hydroxybenzylidene)amino)-10-hydroxy-5H-phenophosphazinine 10-oxide 、 巯基乙酸 以 N,N-二甲基甲酰胺 为溶剂， 以84.5%的产率得到2-(3-ethoxy-4-hydroxyphenyl)-3-(10-hydroxy-10-oxo-5H-phenophosphazinin-2-yl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Novel Organophosphorus Compounds as Potential Antimicrobial Agents

  摘要：

  The 4-Thiazolidinone derivatives of phenophosphazines were synthesized by a reaction of Schiff base derivative of phenophosphazine with Thyoglycollic acid in molar ratio of 1:3 using DMF as solvent. Possible structures have been proposed based on elemental analysis, IR and H-1 NMR spectral studies. The antibacterial and antifungal activities of these derivatives have been evaluated against pathogens E. coli, S. typhi, S. aureus, B. subtilis, A. niger, and C. Albicans.

  DOI：

  10.1080/10426500701640827
• 作为产物：
  描述：

  乙基香兰素 、 2-amino-5,10-dihydrophenophosphazin-10-ol-10-oxide 以 甲醇 为溶剂， 以75%的产率得到2-((3-ethoxy-4-hydroxybenzylidene)amino)-10-hydroxy-5H-phenophosphazinine 10-oxide
  参考文献：
  名称：

  Synthesis and Antimicrobial Activity of Substituted Phenophosphazines

  摘要：

  Several Schiff base derivatives of phenophosphazines were synthesized by the reaction of amino phenophosphazines and aromatic aldehydes in equimolar ratio, using methanol as solvent. Possible structures have been proposed on the basis of elemental analysis, IR, and H-1 NMR spectral studies. The antibacterial and antifungal activities of the above mentioned Schiff base derivatives have been evaluated against pathogens E. coli, S. typhi, S. aureus, B. subtilis, A. niger, and C. Albicans.

  DOI：

  10.1080/10426500801968144