1-(4-(4-chlorophenyl)-2-methyl-1-p-tolyl-1H-pyrrol-3-yl)ethanone | 1456593-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(4-(4-chlorophenyl)-2-methyl-1-p-tolyl-1H-pyrrol-3-yl)ethanone
• CAS: 1456593-29-5
• 化学式: C₂₀H₁₈ClNO
• 分子量: 323.822
• InChiKey: UUDHVVWMWGOFEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.62
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  22.0
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  1-(4-氯苯基)-2-硝基乙烯 、 乙烷,三氯氟- 、 乙酰丙酮 在 cerium(III) chloride heptahydrate 作用下， 以 硝基甲烷 为溶剂， 反应 0.25h， 以55%的产率得到1-(4-(4-chlorophenyl)-2-methyl-1-p-tolyl-1H-pyrrol-3-yl)ethanone
  参考文献：
  名称：

  Modular CeCl3·7H2O-catalyzed multi-component synthesis of 1,2,3,4-tetrasubstituted pyrroles under microwave irradiation and their further trichloroisocyanuric acid-mediated conversion into 5-sulfenylpyrrole derivatives

  摘要：

  A modular, multicomponent synthesis of 1,2,3,4-tetrasubstituted pyrroles promoted by the inexpensive CeCl3 center dot 7H(2)O, is reported. The reaction was carried out under microwave irradiation, affording good yields of products in short time. Scope and limitations were explored and a plausible reaction mechanism is discussed. The resulting heterocycles were smoothly and efficiently converted into their corresponding 5-arylsulfenyl derivatives by reaction with diaryl disulfides and trichloroisocyanuric acid in EtOAc. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.08.035

文献信息

• An efficient synthesis of highly substituted functionalized pyrroles via a four-component coupling reaction catalyzed by Fe(III)-Schiff base/SBA-15
  作者：Ghasem Rezanejade Bardajee、Aseyeh Ghaedi、Hamideh Hazrati、Farnaz Jafarpour

  DOI：10.1080/24701556.2020.1744650

  日期：2020.12.1

  Abstract An environmentally friendly, straightforward, and cheap synthesis of highly substituted functionalized pyrrole derivatives via one pot four-component reactions of 1,3-dicarbonyl compounds, amines, aromatic aldehydes, and nitroalkanes have been developed. This methodology provides desired pyrroles in good-to-excellent yields in the presence of Fe (III)-Schiff base/SBA-15 as a heterogeneous

  摘要 通过1，3-二羰基化合物，胺，芳族醛和硝基烷的一锅四组分反应，已经开发了一种环境友好，直接且廉价的高取代官能化吡咯衍生物的合成方法。该方法在Fe（III）-席夫碱/ SBA-15作为非均相催化剂存在下，以良好至优异的产率提供了所需的吡咯。