5,5-diphenyl-3-(p-tolyl)imidazolidine-2,4-dione | 137606-46-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5,5-diphenyl-3-(p-tolyl)imidazolidine-2,4-dione
• 英文别名: 5,5-diphenyl-3-(4-methylphenyl)hydantoin；3-(4-Methylphenyl)-5,5-diphenylimidazolidine-2,4-dione
• CAS: 137606-46-3
• 化学式: C₂₂H₁₈N₂O₂
• 分子量: 342.397
• InChiKey: HEGOQHQKGSDSBS-UHFFFAOYSA-N

物化性质

• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以65%的产率得到5,5-diphenyl-3-(p-tolyl)imidazolidine-2,4-dione
  参考文献：
  名称：

  Abdel-Hamid, Hoda A.; Fahmy, A.F.M.; Shiba, S.A., Egyptian Journal of Chemistry, 1993, vol. 36, # 3, p. 167 - 176

  摘要：

  DOI：

文献信息

• Amide N-arylation with p-tolyllead triacetate
  作者：Filar López-Alvarado、Carmen Avendaño、J. Carlos Menéndez

  DOI：10.1016/s0040-4039(00)61799-9

  日期：1992.11

  The N-arylation of several types of amidic nitrogen atoms, including those found in carboxamides, sulfonamides, carboxylic acid imides, mixed carboxylic-sulfonic imides and hydantoin systems was carried out by treatment of their sodium salts with p-tolyllead triacetate in the presence of copper (II) acetate.

  几种酰胺型氮原子的N-芳基化反应，包括在羧酰胺，磺酰胺，羧酸酰亚胺，混合的羧酸-磺酸酰亚胺和乙内酰脲体系中发现的那些，通过在对乙酰苯三乙酸三乙酸酯的存在下处理它们的钠盐来进行。醋酸铜（II）。
• Cu-catalyzed <i>N</i>-3-Arylation of Hydantoins Using Diaryliodonium Salts
  作者：Linn Neerbye Berntsen、Ainara Nova、David S. Wragg、Alexander H. Sandtorv

  DOI：10.1021/acs.orglett.0c00642

  日期：2020.4.3

  A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing

  描述了用于乙内酰脲的N -3-芳基化的一般的Cu催化的区域选择性方法。该方案在三乙胺和催化量的简单铜盐存在下，将甲苯磺酸芳基（三甲氧基苯基）碘鎓用作芳基化剂。该方法与结构上不同的乙内酰脲兼容，并且可以与中性芳基或带有弱供电子/吸出元素的芳基一起很好地操作。它也适用于药学上相关的乙内酰脲的快速多样化。
• New Synthetic Applications of Aryllead Triacetates. <i>N</i>-Arylation of Amides
  作者：Pilar López-Alvarado、Carmen Avendaño、J. Carlos Menéndez

  DOI：10.1021/jo960566z

  日期：1996.1.1

  p-Tolyllead triacetate efficiently arylates the nitrogen atom of carboxamide, sulfonamide, imide, and hydantoin anions under mild conditions. This reaction did not interfere with the arylation of amino and beta-dicarbonyl groups.
• Synthesis of Hydantoins, Thiohydantoins, and Glycocyamidines Under Solvent-Free Conditions
  作者：Imran Ali Hashmi、Afshan Aslam、Syed Kashif Ali、Viqar-uddin Ahmed、Firdous Imran Ali

  DOI：10.1080/00397910903320662

  日期：2010.8.31

  Hydantoins, thiohydantoins, and glycocyamidines have been prepared in moderate to excellent yields at room temperature under solvent-free conditions. 3N-amino and carboamide derivatives of hydantoin (7-8) were prepared in single step by condensing benzil with semicarbazide and biuret respectively.
• SCHRAMM, H. W.;REIDLINGER, H.;WENDELIN, W., SCI. PHARM., 58,(1990) N, C. 375-388
  作者：SCHRAMM, H. W.、REIDLINGER, H.、WENDELIN, W.

  DOI：——

  日期：——