3-alanylamino-butyric acid | 136789-30-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 3-alanylamino-butyric acid
• 英文别名: Alanyl-(β-amino-buttersaeure)；3-Alanylamino-buttersaeure；β-(α-Amino-propionyl-amino)-buttersaeure；3-(2-Aminopropanoylamino)butanoic acid
• CAS: 136789-30-5
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: CGAVXOBQNQPYAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-(2-bromo-propionylamino)-butyric acid 在 氨 、 水 作用下， 生成 3-alanylamino-butyric acid
  参考文献：
  名称：

  Kay, Justus Liebigs Annalen der Chemie, 1908, vol. 362, p. 348

  摘要：

  DOI：

文献信息

• SMALL MOLECULE RAC OR RHO INHIBITORS
  申请人：Ohio State Innovation Foundation

  公开号：US20170112896A1

  公开（公告）日：2017-04-27

  Disclosed herein are methods of inhibiting Rac or Rho in a cell or tissue or for treating a disease mediated at least in part by Rac or Rho, using a compound of the formula:
• SMALL MOLECULE RAS INHIBITORS
  申请人：Briesewitz Roger

  公开号：US20170304383A1

  公开（公告）日：2017-10-26

  Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. In another aspect, provided is an antibody-drug-conjugate comprising an antibody conjugated with a compound described herein. In still another aspect, provided is a pharmaceutical composition comprising a compound or antibody-drug-conjugate described herein. In a further aspect, provided is method of treating a cancer comprising administering a therapeutically effective amount of a compound or antibody-drug-conjugate described herein to a patient in need thereof.