4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺 | 312756-74-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺
• 英文名称: 3-benzylsulfamoyl-4-bromo-N-(4-bromophenyl)benzamide
• 英文别名: RS-1；3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide
• CAS: 312756-74-4
• 化学式: C₂₀H₁₆Br₂N₂O₃S
• mdl: MFCD00348720
• 分子量: 524.233
• InChiKey: SWKAVEUTKGKHSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-溴苯甲酸 在 氯磺酸 、 草酰氯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 28.25h， 生成 4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺
  参考文献：
  名称：

  [EN] METHODS OF TREATING CANCER USING RAD51SMALL MOLECULE STIMULATORS
  [FR] PROCÉDÉS DE TRAITEMENT DU CANCER À L'AIDE DE STIMULATEURS DE MOLÉCULES RAD51SMALL

  摘要：

  通过给予刺激RAD51活性的化合物来杀死或抑制癌细胞和肿瘤的生长，并治疗癌症的方法。过度表达RAD51或在同源重组机制中存在其他不平衡的细胞特别容易成为RAD51刺激剂的靶点。

  公开号：

  WO2015138377A1

文献信息

• MEDIUM FOR DIRECT DIFFERENTIATION OF PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELL, METHOD FOR PREPARING MESENCHYMAL STEM CELL BY USING SAME, AND MESENCHYMAL STEM CELL PREPARED THEREBY
  申请人：CHA Biotech Co., Ltd.

  公开号：EP3848455A1

  公开（公告）日：2021-07-14

  The present invention relates to a medium for direct differentiation of embryonic stem cell-derived mesenchymal stem cells, a method of preparing mesenchymal stem cells by using same, mesenchymal stem cells prepared thereby, and a cell therapy product comprising the same mesenchymal stem cells. In a medium composition and a method according to an embodiment, mesenchymal stem cells may be prepared at high yield within a short period of time. In addition, the method is simple in preparation procedure because of the absence of an embryoid body formation step and allows homogeneous cells to be prepared, thus advantageously providing a cell therapy product within a reduce period of time, compared to conventional methods.

  本发明涉及一种用于直接分化胚胎干细胞衍生间充质干细胞的培养基、使用该培养基制备间充质干细胞的方法、由此制备的间充质干细胞以及包含相同间充质干细胞的细胞治疗产品。根据一个实施方案中的培养基组合物和方法，间充质干细胞可在短时间内高产制备。此外，由于没有胚状体形成步骤，该方法制备程序简单，可制备均质细胞，因此与传统方法相比，可在较短时间内提供细胞治疗产品。
• TRANSGENIC ANIMALS AND METHOD FOR BIOPRODUCTION
  申请人：Applied Stemcell, Inc.

  公开号：EP3562944A1

  公开（公告）日：2019-11-06
• METHODS AND COMPOSITIONS FOR MODULATING RAD51 AND HOMOLOGOUS RECOMBINATION
  申请人：Connell Philip P.

  公开号：US20100248371A1

  公开（公告）日：2010-09-30

  The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
• Methods and Compositions for Modulating Rad51 and Homologous Recombination
  申请人：The University of Chicago

  公开号：US20140142103A1

  公开（公告）日：2014-05-22

  The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
• METHODS OF TREATING CANCER USING RAD51 SMALL MOLECULE STIMULATORS
  申请人：The University of Chicago

  公开号：US20170014360A1

  公开（公告）日：2017-01-19

  Methods of killing or inhibiting the growth cancer cells and tumors and of treating cancer by administering compounds that stimulate the activity of RAD51. Cells overexpressing RAD51 or with other imbalances in homologous recombination machinery are particularly susceptible targets of RAD51 stimulators.