2-[4,5-bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-acetamide | 39908-44-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4,5-bis-(4-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-acetamide
• 英文别名: 2-[[4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl]sulfanyl]acetamide
• CAS: 39908-44-6
• 化学式: C₁₉H₁₉N₃O₃S
• 分子量: 369.444
• InChiKey: NTUVBYQFVLYOGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 2-Mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors
  申请人：——

  公开号：US20040116695A1

  公开（公告）日：2004-06-17

  The invention relates to the 2-mercapto-4,5-diarylimidazole derivatives of formula (I), wherein R 1 , R 2 , R 3 and R 4 are defined as in the description. The inventive compounds have an immunomodulatory and cyclooxygenase-inhibiting activity and are therefore suitable for the treatment of diseases that are associated with a disturbed immune system.

  本发明涉及公式(I)的2-巯基-4,5-二芳基咪唑衍生物，其中R1、R2、R3和R4如描述中所定义。该发明化合物具有免疫调节和环氧合酶抑制活性，因此适用于治疗与免疫系统紊乱有关的疾病。
• 2-Mercapto-4,5-Diarylimidazole Derivatives and the use thereof as Cyclooxygenase Inhibitors
  申请人：Dannhardt Gerd

  公开号：US20070185169A1

  公开（公告）日：2007-08-09

  The invention relates to the 2-mercapto-4,5-diarylimidazole derivatives of formula (I), wherein R 1 , R 2 , R 3 and R 4 are defined as in the description. The inventive compounds have an immunomodulatory and cyclooxygenase-inhibiting activity and are therefore suitable for the treatment of disease that are associated with a disturbed immune system.

  本发明涉及公式（I）中的2-巯基-4,5-二芳基咪唑衍生物，其中R1、R2、R3和R4如说明书中所定义。这些创新化合物具有免疫调节和环氧合酶抑制活性，因此适用于治疗与免疫系统紊乱相关的疾病。
• US7223781B2
  申请人：——

  公开号：US7223781B2

  公开（公告）日：2007-05-29