N-[5-chloro-2-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-3-(4-chloro-phenyl)-propionamide | 1159704-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[5-chloro-2-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-3-(4-chloro-phenyl)-propionamide
• 英文别名: N-[5-chloro-2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]-3-(4-chlorophenyl)propanamide
• CAS: 1159704-75-2
• 化学式: C₁₇H₁₃Cl₂N₃O₃
• 分子量: 378.215
• InChiKey: ZQVHEHWIMMIDIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  79.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS<br/>[FR] NOUVEAUX DERIVES DE PHENYL-ACETAMIDE ET DE PHENYL-PROPIONAMIDE UTILES EN TANT QUE MODULATEURS DES CANAUX POTASSIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2009068557A1

  公开（公告）日：2009-06-04

  This invention relates to novel phenyl-acetamide and phenyl- propionamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  这项发明涉及新型苯乙酰胺和苯丙酰胺衍生物，发现它们是钾通道的有效调节剂，因此是治疗各种对钾通道调节敏感的疾病或紊乱的有价值候选药物。
• NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS
  申请人：Nardi Antonio

  公开号：US20100292283A1

  公开（公告）日：2010-11-18

  This invention relates to novel phenyl-acetamide and phenyl-propionamide derivatives that are found to be potent modulators of potassium channels and, as such, are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to the modulation of potassium channels.

  本发明涉及一种新型苯乙酰胺和苯丙酰胺衍生物，发现它们是钾通道的有效调节剂，因此是治疗对钾通道调节敏感的疾病或疾病的有价值的候选药物。