5-bromo-6-chloro-1H-benzo[d]imidazol-2(3H)-one | 1388057-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-bromo-6-chloro-1H-benzo[d]imidazol-2(3H)-one
• 英文别名: 5-bromo-6-chloro-2,3-dihydro-1H-1,3-benzodiazol-2-one；5-bromo-6-chloro-1,3-dihydrobenzimidazol-2-one
• CAS: 1388057-23-5
• 化学式: C₇H₄BrClN₂O
• 分子量: 247.479
• InChiKey: KBTLCMJLOSQEDO-UHFFFAOYSA-N

物化性质

• 沸点：
  216.8±33.0 °C(Predicted)
• 密度：
  1.830±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-bromo-6-chloro-1H-benzo[d]imidazol-2(3H)-one 、 碘甲烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 12.17h， 以87%的产率得到5-bromo-6-chloro-1,3-dimethyl-1H-benzo[d]imidazol-2(3H)-one
  参考文献：
  名称：

  [EN] HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER
  [FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2017205536A3
• 作为产物：
  描述：

  4-溴-5-氯-2-硝基苯胺 在 tin(II) chloride dihdyrate 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 4.0h， 生成 5-bromo-6-chloro-1H-benzo[d]imidazol-2(3H)-one
  参考文献：
  名称：

  [EN] HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER
  [FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2017205536A3

文献信息

• Therapeutic compounds and uses thereof
  申请人：GENENTECH, INC.

  公开号：US10696655B2

  公开（公告）日：2020-06-30

  The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

  本发明涉及式（I）和式（II）化合物： 及其盐，其中式(I)的 R1-R4 和式(II)的 R5-R6 具有本文定义的任一值，以及其组合物和用途。这些化合物可用作 CBP 和/或 EP300 的抑制剂。还包括包含式(I)的式(II)的化合物或其药学上可接受的盐的药物组合物，以及使用这种化合物和盐治疗各种CBP和/或EP300介导的疾病的方法。
• HETEROCYCLIC INHIBITORS OF CBP/EP300 AND THEIR USE IN THE TREATMENT OF CANCER
  申请人：Genentech, Inc.

  公开号：EP3464270A2

  公开（公告）日：2019-04-10
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：GENENTECH, INC.

  公开号：US20190152949A1

  公开（公告）日：2019-05-23

  The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R 1 -R 4 of formula (I) and R 5 -R 6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2017205536A2

  公开（公告）日：2017-11-30

  The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.