3-methyl-2-phenylchroman | 1383125-38-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-methyl-2-phenylchroman
• 英文别名: 3-methyl-2-phenyl-3,4-dihydro-2H-chromene
• CAS: 1383125-38-9
• 化学式: C₁₆H₁₆O
• 分子量: 224.302
• InChiKey: QOXDGKHIFWXYED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl-2-phenylchroman 、 氯仿 、 苄基三乙基氯化铵 以52%的产率得到
  参考文献：
  名称：

  KOBLIK A. V.; SUZDALEV K. F.; LOKTIONOV A. A., XIMIYA GETEROTSIKL. SOED.,(1987) N 2, 188-194

  摘要：

  DOI：
• 作为产物：
  描述：

  (Z)-3-(2-Hydroxy-phenyl)-2-methyl-1-phenyl-propenone 在 三乙基硅烷 、 indium(III) chloride 作用下， 以 乙腈 为溶剂， 反应 15.0h， 以54%的产率得到3-methyl-2-phenylchroman
  参考文献：
  名称：

  通过切换溶剂，使用InCl 3 / Et 3 SiH系统一锅法合成O-杂环或芳基酮

  摘要：

  使用Int 3 SiH的Et 3 SiH通过转换溶剂进行顺序离子氢化反应，可以在InCl 3存在下实现O-杂环或芳基酮的有效一锅合成。该方法可用于轻松构建C–O键并制备共轭物还原产物，包括苯并二氢吡喃，四氢呋喃，四氢吡喃，二氢异苯并呋喃，二氢查耳酮和1,4-二酮。另外，通过实验研究证实了涉及共轭物还原和串联还原性环化的新型合理机制。

  DOI：

  10.1021/acs.joc.9b00140

文献信息

• Me3SiI-promoted reaction of salicylic aldehydes with ketones: a facile way to construct benzopyranic [2,3-b]ketals and spiroketals
  作者：Feijun Wang、Mingliang Qu、Xi Lu、Feng Chen、Feng Chen、Min Shi

  DOI：10.1039/c2cc32545d

  日期：——

  Me3SiI-promoted reaction of salicylic aldehydes with ketones via arylmethylation at the α-site of the carbonyl group and cyclodehydration of keto-diol provided a facile way to construct heteroannular ketals, furnishing benzopyranic [2,3-b]ketals and spiroketals in moderate to good yields.

  在 Me3SiI 的促进下，水杨醛与酮通过羰基 α 位芳基甲基化反应和酮二醇的环脱水反应，以中等至较好的产率构建了杂环酮，并得到了苯并吡喃 [2,3-b] 酮和螺酮。
• Benzopyran compounds, useful as chemotherapeutic agents
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0025599A1

  公开（公告）日：1981-03-25

  Known and novel compounds of formula (I) wherein R4 is hydrogen or lower alkyl, R3 is hydrogen or lower alkyl and R5 is a substituent, or R3 and R5 together form a group -CH2- or -CH2-CH2-, and R1 and R2 each represent four substituents or one or both R1 and R2 represents a methylenedioxy group and two substituents are active against viruses, especially rhinoviruses. Methods for producing the compounds are described, as are pharmaceutical formulations and methods for administering the compounds to cure or prevent rhinoviral infections.

  已知和新型的式(I)化合物 其中 R4 是氢或低级烷基，R3 是氢或低级烷基，R5 是一个取代基，或 R3 和 R5 共同组成一个基团-CH2-或- - -，R1 和 R2 各代表四个取代基，或 R1 和 R2 之一或二者代表一个亚甲基二氧基基团和两个取代基，对病毒，特别是鼻病毒具有活性。本文介绍了生产这些化合物的方法，以及使用这些化合物治疗或预防鼻病毒感染的药物制剂和方法。
• Esters of flavonoids with w-substituted c6-c22 fatty acids
  申请人：Moussou Philippe

  公开号：US20070184098A1

  公开（公告）日：2007-08-09

  Esters of flavonoids, including flavones, flavonols, flavanones, flavanols, flavanolols, isoflavones, anthocyanins, proanthocyanidins, chalcones, aurones and hydroxycoumarins conjugated by an ester bond to a ω-substituted C6 to C22 fatty acid are provided. The esters may be used in cosmetic, pharmaceutical, and nutritional preparations.
• Stabilized 3-Hydroxyflavan Compositions and Methods Therefor
  申请人：Hara Yukihiko

  公开号：US20080300302A1

  公开（公告）日：2008-12-04

  Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.
• METHOD FOR PRODUCING FLAVAN DERIVATIVE
  申请人：Suzuki Keisuke

  公开号：US20090099374A1

  公开（公告）日：2009-04-16

  The present invention provides a method for producing flavan derivatives having various substituent groups with controlling the stereochemistry. The method of the present invention includes the steps of: hydratively condensing a phenol compound expressed by formula (I) and an alcohol compound expressed by formula (II) to from an epoxide compound of formula (III); opening the epoxy ring of the epoxide compound of formula (III) to form an iodine-containing compound of formula (IV); and cyclizing the iodine-containing compound to form the flavan derivative of formula (V).