3-(propyl)isoxazole | 30842-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(propyl)isoxazole
• 英文别名: 3-(N-propyl)isoxazole；3-n-Propylisoxazol；3-Propyl-isoxazol；Propylisoxazole；3-propyl-1,2-oxazole
• CAS: 30842-94-5
• 化学式: C₆H₉NO
• 分子量: 111.144
• InChiKey: AYTLPTRYSGTHNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  vinyl phenyl selenide 、 Butyronitrile oxide 在 三乙胺 、 双氧水 作用下， 以 氯仿 为溶剂， 反应 12.33h， 生成 3-(propyl)isoxazole
  参考文献：
  名称：

  由苯基乙烯基硒化物一锅法合成3-取代异恶唑

  摘要：

  采用苯基乙烯基硒化物对腈氧化物进行 1,3-双极环加成反应，随后氧化消除提供 3-取代的异恶唑，在一锅两步转化中具有良好的收率。

  DOI：

  10.1055/s-2003-44354

文献信息

• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2015135094A1

  公开（公告）日：2015-09-17

  The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

  本发明涉及作为一个或多个组蛋白去甲基化酶抑制剂的化合物。该发明还提供了包括本发明化合物的药用可接受组合物，以及使用这些组合物治疗各种疾病的方法。
• SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20160031830A1

  公开（公告）日：2016-02-04

  Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD. Exemplary is

  式1的替代二氢嘧啶酮是中性粒细胞弹性蛋白酶抑制剂，可用作治疗COPD等疾病的药物。
• [EN] PYRAZOLE DERIVATIVES WHICH MODULATE STEAROYL-COA DESATURASE<br/>[FR] DÉRIVÉS DE PYRAZOLE QUI MODULENT LA STÉAROYL-COA DÉSATURASE
  申请人：NOVARTIS AG

  公开号：WO2011039358A1

  公开（公告）日：2011-04-07

  The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

  本发明提供了能够调节硬脂酰辅酶A脱饱和酶活性的杂环衍生物。还涵盖了利用这些衍生物调节硬脂酰辅酶A脱饱和酶活性的方法以及包含这些衍生物的药物组合物。
• [EN] METHOD AND APPARATUS FOR THE SYNTHESIS OF DIHYDROARTEMISININ AND ARTEMISININ DERIVATIVES<br/>[FR] PROCÉDÉ ET APPAREIL DE SYNTHÈSE DE DIHYDROARTÉMISININE ET DE DÉRIVÉS D'ARTÉMISININE
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V

  公开号：WO2015007693A1

  公开（公告）日：2015-01-22

  The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.

  本发明涉及一种连续生产二氢青蒿素以及由二氢青蒿素衍生的青蒿素衍生物的方法，该方法利用青蒿素或二氢青蒿酸（DHAA）作为起始物质，并且涉及一种用于生产二氢青蒿素以及青蒿素衍生物的连续流反应器。发现在连续过程中将青蒿素还原为二氢青蒿素需要一种特殊类型的反应器和一种特殊的试剂组合，包括一种氢化物还原剂，至少一种活化剂（例如无机活化剂），至少一种固体碱，至少一种无极性溶剂以及至少一种C1-C5醇。
• Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2826779A1

  公开（公告）日：2015-01-21

  The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C1-C5 alcohol.

  本发明涉及一种连续生产二氢青蒿素以及由二氢青蒿素衍生的青蒿素衍生物的方法，该方法利用青蒿素或二氢青蒿酸（DHAA）作为起始物质，并且涉及一种用于生产二氢青蒿素以及青蒿素衍生物的连续流反应器。发现在连续过程中将青蒿素还原为二氢青蒿素需要一种特殊类型的反应器以及包括氢化还原剂、至少一种活化剂（如无机活化剂）、至少一种固体碱、至少一种无水溶剂和至少一种C1-C5醇的特殊组合的试剂。