5-(4'-methoxy-phenylazo)-2-amino-4-phenyl-thiazole | 26179-14-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4'-methoxy-phenylazo)-2-amino-4-phenyl-thiazole
• 英文别名: 5-[2-(4-methoxyphenyl)diazen-1-yl]-4-phenyl-1,3-thiazol-2-amine；5-(4-methoxy-phenylazo)-4-phenyl-thiazol-2-ylamine；5-[2-(4-Methoxyphenyl)diaz-1-enyl]-4-phenyl-1,3-thiazol-2-amine；5-[(4-methoxyphenyl)diazenyl]-4-phenyl-1,3-thiazol-2-amine
• CAS: 26179-14-6
• 化学式: C₁₆H₁₄N₄OS
• 分子量: 310.379
• InChiKey: KWZAFIFHUGHTGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-(4'-methoxy-phenylazo)-2-amino-4-phenyl-thiazole 、 乙烯基三乙氧基硅烷 以 四氢呋喃 为溶剂， 反应 4.0h， 以45%的产率得到5-[2-(4-methoxyphenyl)diazen-1-yl]-4-phenyl-N-[2-(triethoxysilyl)ethyl]-1,3-thiazol-2-amine
  参考文献：
  名称：

  Sol–gel synthesis of organic–inorganic hybrid materials comprising boehmite, silica, and thiazole dye

  摘要：

  A hybrid material was prepared from a boehmite sol and a thiazole derived azo dye. The thiazole azo dyes were subjected to hydrolytic polycondensation with vinyltriethoxysilane, tetraethoxysilane, and aluminium isopropoxide in different ratios to afford a hybrid of boehmite, silica, and the thiazole heterocycle azo dye. The structures of these hybrid materials were characterized using X-ray diffraction, Fourier-transform infrared analysis, Si-29- and Al-27-nuclear magnetic resonance, ultraviolet-visible absorption spectrophotometry, and an energy-dispersive X-ray spectroscopy. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2012.01.020
• 作为产物：
  描述：

  2-氨基-4-苯基噻唑 、 甲氧苯胺 在 盐酸 、 硫酸 、 sodium nitrite 、 sodium carbonate 作用下， 以 水 为溶剂， 反应 0.33h， 生成 5-(4'-methoxy-phenylazo)-2-amino-4-phenyl-thiazole
  参考文献：
  名称：

  The synthesis of vinyltriethoxysilane-modified heteroaryl thiazole dyes and silica hybrid materials

  摘要：

  Hybrid materials composed of tetraethoxysilane and heteroaryl 4-substituent-2-aminothiazoles were prepared. 4-Substituted acetophenone, thiourea and iodide were used to generate the intermediate, 4-substituted-2-aminothiazole, as coupling component, which was then coupled with p-nitroaniline and p-methoxyaniline to yield heteroaryl 4-substitued thiazole azo dyes. The dyes subsequently underwent hydrolytic polycondensation with vinyltriethoxysilane and tetraethoxysilane to yield hybrid, heteroaryl thiazole azo dyes, whose chemical structure was characterized using FT-IR, Si-29 NMR, H-1 NMR and EDS. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.dyepig.2009.12.006

文献信息

• Shawali,A.S.; Abdelhamid,A.O., Journal of Heterocyclic Chemistry, 1976, vol. 13, p. 45 - 49
  作者：Shawali,A.S.、Abdelhamid,A.O.

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ag: MVol.B6, 1.16.1, page 285 - 291
  作者：

  DOI：——

  日期：——
• Rao; Khan; Mehra, Journal of the Indian Chemical Society, 1982, vol. 59, # 3, p. 375 - 377
  作者：Rao、Khan、Mehra

  DOI：——

  日期：——
• Potential antineoplastics II: 1-Thiocarbamoyl-3-methyl 4-arylhydrazono-2-pyrazolin-5-ones, 2-Amino-4-phenyl-5-arylazothiazoles, and N-Phenyl-N′-2(4-phenyl-5-arylazothiazolyl)thiocarbamides
  作者：H.G. Garg、R.A. Sharma

  DOI：10.1002/jps.2600590316

  日期：1970.3
• Jain, Rajeev; Tyagi, Sudha; Agarwal, Sharad, Journal of the Indian Chemical Society, 1981, vol. 58, # 11, p. 1112 - 1113
  作者：Jain, Rajeev、Tyagi, Sudha、Agarwal, Sharad

  DOI：——

  日期：——