3-(2-chlorobenzylidene)flavanone | 234093-70-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-(2-chlorobenzylidene)flavanone
• 英文别名: (3E)-3-[(2-chlorophenyl)methylidene]-2-phenylchromen-4-one
• CAS: 234093-70-0
• 化学式: C₂₂H₁₅ClO₂
• 分子量: 346.813
• InChiKey: WIBPUZAXVOPNDF-JXAWBTAJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-chlorobenzylidene)flavanone 、 2-氨基-5-溴苯硫醇 在 三氟乙酸 作用下， 以 甲苯 为溶剂， 反应 6.0h， 以67%的产率得到10-bromo-7-(2-chlorophenyl)-6-phenyl-6a,7-dihydro-6H-chromeno[3,4-c][1,5]benzothiazepine
  参考文献：
  名称：

  Syntheses of 1,5-Benzothiazepines-Part XXXI: Syntheses and Antimicrobial Studies of 10-Substituted-7- (monochlorophenyl/dichlorophenyl)-6H-6a,7-dihydro-6-phenyl[1]benzopyrano[3,4-c]-[1,5]benzothiazepines

  摘要：

  Two flavindogenides, 3-(2-chlorobenzylidene)-flavanone and 3-(2,4-dichlorobenzylidene)-flavanone reacted with six 5-substittited-2-aminobenzenethiols, the substituents being fluoro, chloro, bromo, methyl, methoxyl, and ethoxyl, to give respective 12 new compounds, 10-substititted-7-(2-chlorophenyl/2,4-dichlorophenyl)-6H-6a,7-dihydro-6-phenyl[1]benzopyrano[3,4-c][1,5]benzothiazepines (5a-1) in 60-70% yields. The products were characterized on the basis of microanalytical data for elements and. IR, H-1, and C-13 NMR and mass spectral studies. All the synthesized compounds were evaluated for their antimicrobial activity against the bacteria, Escherichia coli and GFC, and the fungi, Aspergillus niger, Aspergillus flavus, and Curvularia lunata.

  DOI：

  10.1080/104265090517325
• 作为产物：
  描述：

  2-氯苯甲醛 、 黄烷酮 在 盐酸 作用下， 以 乙醇 为溶剂， 以42%的产率得到3-(2-chlorobenzylidene)flavanone
  参考文献：
  名称：

  Syntheses of 1,5-Benzothiazepines-Part XXXI: Syntheses and Antimicrobial Studies of 10-Substituted-7- (monochlorophenyl/dichlorophenyl)-6H-6a,7-dihydro-6-phenyl[1]benzopyrano[3,4-c]-[1,5]benzothiazepines

  摘要：

  Two flavindogenides, 3-(2-chlorobenzylidene)-flavanone and 3-(2,4-dichlorobenzylidene)-flavanone reacted with six 5-substittited-2-aminobenzenethiols, the substituents being fluoro, chloro, bromo, methyl, methoxyl, and ethoxyl, to give respective 12 new compounds, 10-substititted-7-(2-chlorophenyl/2,4-dichlorophenyl)-6H-6a,7-dihydro-6-phenyl[1]benzopyrano[3,4-c][1,5]benzothiazepines (5a-1) in 60-70% yields. The products were characterized on the basis of microanalytical data for elements and. IR, H-1, and C-13 NMR and mass spectral studies. All the synthesized compounds were evaluated for their antimicrobial activity against the bacteria, Escherichia coli and GFC, and the fungi, Aspergillus niger, Aspergillus flavus, and Curvularia lunata.

  DOI：

  10.1080/104265090517325