2-(3-aminophenyl)pent-4-en-2-ol | 933746-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-aminophenyl)pent-4-en-2-ol
• CAS: 933746-01-1
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: ZWCMLAMPKZGRII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  间氨基苯乙酮 、 烯丙基硼酸频哪醇酯 在 乙醇 、 diethylzinc 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以96%的产率得到2-(3-aminophenyl)pent-4-en-2-ol
  参考文献：
  名称：

  Mild and General Zinc-Alkoxide-Catalyzed Allylations of Ketones with Allyl Pinacol Boronates

  摘要：

  A general and efficient zinc-alkoxide-catalyzed allylation of a diverse array of ketones with allyl boronates is presented. The methodology is effective with 2 mol % of catalyst and with relatively short reaction times. Studies of the key exchange process are presented, which support a cyclic transition state for the boron to zinc exchange.

  DOI：

  10.1021/ol101301s

文献信息

• Allylation and Crotylation of Ketones and Aldehydes Using Potassium Organotrifluoroborate Salts under Lewis Acid and Montmorillonite K10 Catalyzed Conditions
  作者：Farhad Nowrouzi、Avinash N. Thadani、Robert A. Batey

  DOI：10.1021/ol900599q

  日期：2009.6.18

  Two convenient highly diastereoselective protocols for the allylation and crotylation of ketones using practical, air- and water-stable potassium allyl and crotyltrifluoroborate salts have been developed. BF3·OEt2 and montmorillonite clay are used as catalysts to promote additions. The montmorillonite-catalyzed method in particular is very robust, providing a straightforward and scalable method for

  已经开发了两种方便的高度非对映选择性方案，用于使用实用的，对空气和水稳定的烯丙基钾盐和巴豆基三氟硼酸盐进行烯丙基化和丁酰化。BF 3 ·OEt 2和蒙脱土用作促进添加的催化剂。蒙脱石催化的方法尤其非常健壮，它为多种酮和醛的烯丙基化和丁烯酰化提供了一种简单易行的方法。
• Mild and General Zinc-Alkoxide-Catalyzed Allylations of Ketones with Allyl Pinacol Boronates
  作者：Keith R. Fandrick、Daniel R. Fandrick、Joe J. Gao、Jonathan T. Reeves、Zhulin Tan、Wenjie Li、Jinhua J. Song、Bruce Lu、Nathan K. Yee、Chris H. Senanayake

  DOI：10.1021/ol101301s

  日期：2010.9.3

  A general and efficient zinc-alkoxide-catalyzed allylation of a diverse array of ketones with allyl boronates is presented. The methodology is effective with 2 mol % of catalyst and with relatively short reaction times. Studies of the key exchange process are presented, which support a cyclic transition state for the boron to zinc exchange.