| 1587712-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• CAS: 1587712-88-6
• 化学式: C₇₆H₁₀₀N₂₀O₈Zn
• 分子量: 1487.15
• InChiKey: WTMTVDRFDBKLCW-MDKZQYJTSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  溴乙酸叔丁酯 、 在 碳酸氢钠 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以0.22g的产率得到
  参考文献：
  名称：

  Tetranuclear Gadolinium(III) Porphyrin Complex as a Theranostic Agent for Multimodal Imaging and Photodynamic Therapy

  摘要：

  We describe herein the elaborate design of a Gd(III)-porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy. Far-red-emitting (665 nm) and high relaxivity (14.1 mM(-1) s(-1)) with 10796 increase upon binding to HSA (human serum albumin) (29.2 mM(-1) s(-1)) together with efficiently generating singlet oxygen upon exposure to far-red light irradiation at 650 +/- 20 nm demonstrate that this Gd(III)-porphyrin complex with four Gd(III)-DTTA units bound to tetraphenylporphyrin acts as a potentially theranostic agent with excellent performance for magnetic resonance imaging, optical imaging, and photodynamic therapy.

  DOI：

  10.1021/ic500238s
• 作为产物：
  描述：

  三(2-氨基乙基)胺 、 meso-5,10,15,20-tetrakis[4-((ethoxycarbonyl)methoxy)-phenyl]porphyrinatozinc(II) 以 乙醇 为溶剂， 反应 48.0h， 以0.46g的产率得到
  参考文献：
  名称：

  Tetranuclear Gadolinium(III) Porphyrin Complex as a Theranostic Agent for Multimodal Imaging and Photodynamic Therapy

  摘要：

  We describe herein the elaborate design of a Gd(III)-porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy. Far-red-emitting (665 nm) and high relaxivity (14.1 mM(-1) s(-1)) with 10796 increase upon binding to HSA (human serum albumin) (29.2 mM(-1) s(-1)) together with efficiently generating singlet oxygen upon exposure to far-red light irradiation at 650 +/- 20 nm demonstrate that this Gd(III)-porphyrin complex with four Gd(III)-DTTA units bound to tetraphenylporphyrin acts as a potentially theranostic agent with excellent performance for magnetic resonance imaging, optical imaging, and photodynamic therapy.

  DOI：

  10.1021/ic500238s