2-chloro-1-(2-chloro-4,6-difluorophenyl)-α-(2-chloro-4-fluorophenyl)-4-methyl-1H-imidazole-5-methanol | 1369394-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-chloro-1-(2-chloro-4,6-difluorophenyl)-α-(2-chloro-4-fluorophenyl)-4-methyl-1H-imidazole-5-methanol
• 英文别名: [2-Chloro-3-(2-chloro-4,6-difluorophenyl)-5-methylimidazol-4-yl]-(2-chloro-4-fluorophenyl)methanol
• CAS: 1369394-70-6
• 化学式: C₁₇H₁₀Cl₃F₃N₂O
• 分子量: 421.633
• InChiKey: OTZCSMZOWNXMKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] FUNGICIDAL IMIDAZOLES<br/>[FR] IMIDAZOLES FONGICIDES
  申请人：DU PONT

  公开号：WO2012044650A1

  公开（公告）日：2012-04-05

  Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, Formula 1 wherein Q1, Q2, R1, R2, R3 and R4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  揭示了公式1的化合物，包括所有立体异构体，N-氧化物和盐，其中公式1中Q1、Q2、R1、R2、R3和R4如披露中定义。还公开了含有公式1化合物的组合物以及控制由真菌病原体引起的植物病害的方法，包括施用本发明的化合物或组合物的有效量。
• FUNGICIDAL IMIDAZOLES
  申请人：Long Jeffrey Keith

  公开号：US20130143929A1

  公开（公告）日：2013-06-06

  Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein Q 1 , Q 2 , R 1 , R 2 , R 3 and R 4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  本发明涉及一种公式1的化合物，包括所有立体异构体，N-氧化物和其盐，其中Q1，Q2，R1，R2，R3和R4如所述。本发明还涉及包含公式1化合物的组合物以及控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。
• Stabilized alpha helical peptides from BCL-2 and uses thereof
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：EP1997828A2

  公开（公告）日：2008-12-03

  Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

  本文描述了新型多肽及其制造和使用方法。这些多肽包括交联（"烃订联"）分子，可在两个氨基酸分子之间提供系链，从而限制多肽的二级结构。本文所述的多肽可用于治疗以细胞过度或不充分死亡为特征的疾病。
• Stabilized alpha helical peptides derived from the BCL2-family for therapy.
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：EP2332967A1

  公开（公告）日：2011-06-15

  Novel apoptotic polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

  本文描述了新型凋亡多肽及其制造和使用方法。这些多肽包括交联（"烃订联"）分子，可在两个氨基酸分子之间提供系链，从而限制多肽的二级结构。本文所述的多肽可用于治疗以细胞过度或不充分死亡为特征的疾病。
• Stabilized alpha helical peptides and uses thereof
  申请人：Walensky D. Loren

  公开号：US20050250680A1

  公开（公告）日：2005-11-10

  Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

  本文描述了新型多肽及其制造和使用方法。这些多肽包括交联（"烃订联"）分子，可在两个氨基酸分子之间提供系链，从而限制多肽的二级结构。本文所述的多肽可用于治疗以细胞过度或不充分死亡为特征的疾病。