N-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl)cyclohexanecarboxamide | 1229515-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-(2-(1-methyl-1H-imidazol-4-ylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl)cyclohexanecarboxamide
• 英文别名: N-[2-(1-methylimidazol-4-yl)sulfonyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-4-yl]cyclohexanecarboxamide
• CAS: 1229515-69-8
• 化学式: C₁₈H₂₈N₄O₃S
• 分子量: 380.511
• InChiKey: DXIVVDJFDWAREB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 3.3.0 BICYCLIC GlyT1 INHIBITORS AND METHODS OF MAKING AND USING SAME
  申请人：Lindsley Craig W.

  公开号：US20100261773A1

  公开（公告）日：2010-10-14

  In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US8211933B2
  申请人：——

  公开号：US8211933B2

  公开（公告）日：2012-07-03