5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-N-(2-methoxyethyl)-N,2-dimethylbenzenesulfonamide | 959465-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-N-(2-methoxyethyl)-N,2-dimethylbenzenesulfonamide
• 英文别名: 5-[3-(2,4-dihydroxy-5-propan-2-ylphenyl)-5-oxo-1H-1,2,4-triazol-4-yl]-N-(2-methoxyethyl)-N,2-dimethylbenzenesulfonamide
• CAS: 959465-56-6
• 化学式: C₂₂H₂₈N₄O₆S
• 分子量: 476.554
• InChiKey: INTSMDJYEAKPAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Triazole compounds that modulate Hsp90 activity
  申请人：Sun Lijun

  公开号：US20080176840A1

  公开（公告）日：2008-07-24

  The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

  本发明涉及替代三唑化合物和包含替代三唑化合物的组合物。该发明还涉及在需要的受试者中抑制Hsp90活性的方法，以及预防或治疗过度增殖性疾病，如癌症，的方法，包括向受试者施用本发明的替代三唑化合物或包含这种化合物的组合物。
• TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY
  申请人：Sun Lijun

  公开号：US20110319447A1

  公开（公告）日：2011-12-29

  The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

  本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在需要的主体中抑制Hsp90活性的方法以及预防或治疗过度增殖性疾病（如癌症）的方法，包括向主体中注射本发明的取代三唑化合物或包含这种化合物的组合物。
• Sugar derivatives comprising oxiranes or alpha, beta-unsaturated gamma-lactones, process for their preparation and their utilisation as pesticides
  申请人：Justino Alberto Guerra Jorge

  公开号：US20070117865A1

  公开（公告）日：2007-05-24

  A method for controlling pests, the method comprising applying an effective amount to pests or their locus of one or more compounds of general formula (I) wherein R 1 and R 2 represent, independently from each other, hydrogen, halogen, alkoxy, substituted alkoxy or an ester group; R 1 and R 2 , together with the carbon atoms to which they are attached, represent an oxirane ring; R 1 and R 2 , taken together, represent an akylidenedioxy or substituted alkylidenedioxy group; and R 3 represents —CH 2 R 6 , wherein R 6 represents an ester group, oxiranyl, or a group of formula wherein R 7 represents hydrogen or alkyl, R 8 represents phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy, and R 9 represents hydrogen, ethoxycarbonyl or carbamoyl; and R 4 represents, independently, hydrogen, alkoxy or substituted alkoxy, or R 1 and R 4 , taken together, represent an alkylidenedioxy or a substituted alkylidenedioxy group; wherein the pest dies as a result of contact with the compound.
• US7538139B2
  申请人：——

  公开号：US7538139B2

  公开（公告）日：2009-05-26
• US7622498B2
  申请人：——

  公开号：US7622498B2

  公开（公告）日：2009-11-24