2-(5-methyloxazol-4-yl)acetic acid | 1507656-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(5-methyloxazol-4-yl)acetic acid
• 英文别名: 5-methyl-4-oxazoleacetic acid；5-Methyloxazole-4-acetic Acid；2-(5-methyl-1,3-oxazol-4-yl)acetic acid
• CAS: 1507656-31-6
• 化学式: C₆H₇NO₃
• 分子量: 141.126
• InChiKey: ORRSLIXXIMTKIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(5-methyloxazol-4-yl)acetic acid 在 hydrazine hydrate 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 为溶剂， 反应 28.0h， 生成 2-(5-methyloxazol-4-yl)acetohydrazide
  参考文献：
  名称：

  [EN] TRIAZOLE COMPOUNDS AS ADENOSINE RECEPTOR ANTAGONISTS
  [FR] COMPOSÉS DE TRIAZOLE UTILES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE L'ADÉNOSINE

  摘要：

  本文描述了式（I）的三唑化合物及其药学上可接受的盐。还描述了制备和使用式（I）化合物的方法。式（I）的化合物及其药学上可接受的盐可用作腺苷受体拮抗剂，例如用于治疗由腺苷受体介导的疾病或症状，如癌症、运动障碍或注意障碍。

  公开号：

  WO2021156439A1

文献信息

• Process for the production of 2-(5-methyl-4-oxazolyl)acetates
  申请人：Japan Tobacco Inc.

  公开号：EP1384722A8

  公开（公告）日：2004-09-08

  The present invention relates to a novel method for producing a compound of the formula [11] wherein R is an optionally substituted aromatic hydrocarbon group, an optionally substituted alicyclic hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted condensed heterocyclic group, which is useful as a therapeutic agent for diabetes. The method of the present invention is an industrially utilizable method that enables efficient production of the objective compound [11] from β-methyl L-aspartate via an important intermediate compound [6] wherein R is as defined above, at high yield.

  本发明涉及一种生产式[11]化合物的新方法，其中R为任选取代的芳香烃基团、任选取代的脂环烃基团、任选取代的杂环基团或任选取代的缩合杂环基团，该化合物可用作糖尿病的治疗剂。本发明的方法是一种可在工业上使用的方法，它能通过一种重要的中间体化合物[6]（其中R如上文所定义）从β-甲基L-天冬氨酸中高效地生产出目标化合物[11]，且收率高。
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• WO2023/147015
  申请人：——

  公开号：——

  公开（公告）日：——