(N-benzoyl)-L-4-amino phenylalanine methyl ester | 93634-78-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (N-benzoyl)-L-4-amino phenylalanine methyl ester
• 英文别名: methyl (2S)-3-(4-aminophenyl)-2-benzamidopropanoate
• CAS: 93634-78-7
• 化学式: C₁₇H₁₈N₂O₃
• 分子量: 298.342
• InChiKey: MRNUKZMLRRBKIL-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (N-benzoyl)-L-4-amino phenylalanine methyl ester 在 N-羟基丁二酰亚胺 、 水 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 lithium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 N-((2S)-3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-1-(cyclohexylamino)-1-oxopropan-2-yl)benzamide
  参考文献：
  名称：

  Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

  摘要：

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

  DOI：

  10.1021/ja108527y
• 作为产物：
  描述：

  (S)-4-硝基苯丙氨酸甲酯 在 溶剂黄146 、 三乙胺 、 锌 作用下， 以 乙醇 为溶剂， 生成 (N-benzoyl)-L-4-amino phenylalanine methyl ester
  参考文献：
  名称：

  Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

  摘要：

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

  DOI：

  10.1021/ja108527y

文献信息

• Phenylalanine derivatives
  申请人：Celltech Therapeutics Limited

  公开号：US06329372B1

  公开（公告）日：2001-12-11

  Phenylalanine derivatives of formula (1) are described: wherein R is a carboxylic acid or a derivative thereof; L1 is a linker atom or group; Het is an optionally substituted heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alpha4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

  描述了式（1）的苯丙氨酸衍生物：其中R为羧酸或其衍生物；L1为连接原子或基团；Het为可选择取代的杂芳基团；以及它们的盐、溶剂合物、水合物和N-氧化物。这些化合物能够抑制α4整合素与其配体的结合，并可用于预防和治疗免疫或炎症性疾病。
• US6197794B1
  申请人：——

  公开号：US6197794B1

  公开（公告）日：2001-03-06
• US6329372B1
  申请人：——

  公开号：US6329372B1

  公开（公告）日：2001-12-11
• Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array
  作者：Hongyu Zhou、Peifu Jiao、Lei Yang、Xi Li、Bing Yan

  DOI：10.1021/ja108527y

  日期：2011.2.2

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.