(-)-2-[5-Methyl-4-([1,2,4]thiadiazol-5-ylcarbamoyl)thiophen-2-yl]pyrrolidine-1-carboxylic acid t-butyl ester | 1259396-37-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (-)-2-[5-Methyl-4-([1,2,4]thiadiazol-5-ylcarbamoyl)thiophen-2-yl]pyrrolidine-1-carboxylic acid t-butyl ester
• 英文别名: 2-[5-methyl-4-([1,2,4]thiadiazol-5-ylcarbamoyl)thiophen-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester；Tert-butyl 2-[5-methyl-4-(1,2,4-thiadiazol-5-ylcarbamoyl)thiophen-2-yl]pyrrolidine-1-carboxylate
• CAS: 1259396-37-6
• 化学式: C₁₇H₂₂N₄O₃S₂
• 分子量: 394.519
• InChiKey: YNQIZFBUPGJEJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  141
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NOVEL THIOPHENECARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Yamashita Tokuyuki

  公开号：US20120101137A1

  公开（公告）日：2012-04-26

  The object of the present invention is to provide a compound having a glucokinase-activating effect. A pharmaceutical composition comprising a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein X means a nitrogen atom or CR 6 , wherein R 6 means a hydrogen atom or a halogen atom; R 1 means a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 alkylthio group; R 2 means a hydrogen atom or a fluorine atom; R 3 means a hydrogen atom or a C1-C6 alkyl group; and one of R 4 and R 5 means a hydrogen atom or a C1-C6 alkyl group, and the other means a C1-C6 alkylenecarboxylic acid, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, or CONH 2 .

  本发明的目的是提供一种具有激活葡萄糖激酶作用的化合物。一种包含以下通式（I）所表示的化合物或其药学上可接受的盐为活性成分的药物组合物：其中X代表一个氮原子或CR6，其中R6代表氢原子或卤素原子；R1代表氢原子、C1-C6烷基、C1-C6烷氧基或C1-C6烷硫基；R2代表氢原子或氟原子；R3代表氢原子或C1-C6烷基；而R4和R5中的一个代表氢原子或C1-C6烷基，另一个代表C1-C6烷基羧酸、C1-C6烷基磺酰基、C1-C6烷基羰基或CONH2。
• NOVEL THIOPHENE CARBOXAMIDE DERIVATIVE AND MEDICINAL USE OF SAME
  申请人：Sanwa Kagaku Kenkyusho Co., Ltd

  公开号：EP2447265A1

  公开（公告）日：2012-05-02

  The object of the present invention is to provide a compound having a glucokinase-activating effect. A pharmaceutical composition comprising a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein X means a nitrogen atom or CR6 wherein R6 means a hydrogen atom or a halogen atom; R1 means a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 alkylthio group; R2 means a hydrogen atom or a fluorine atom; R3 means a hydrogen atom or a C1-C6 alkyl group; and one of R4 and R5 means a hydrogen atom or a C1-C6 alkyl group, and the other means a C1-C6 alkylenecarboxylic acid, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, or CONH2.

  本发明的目的是提供一种具有葡萄糖激酶激活作用的化合物。 一种药物组合物，其活性成分包括通式（I）代表的化合物或其药学上可接受的盐： 其中 X 指氮原子或 CR6，其中 R6 指氢原子或卤素原子； R1 指氢原子、C1-C6 烷基、C1-C6 烷氧基或 C1-C6 烷硫基； R2 指氢原子或氟原子 R3 指氢原子或 C1-C6 烷基；以及 R4 和 R5 中的一个指氢原子或 C1-C6 烷基，另一个指 C1-C6 烷烯羧酸、C1-C6 烷基磺酰基、C1-C6 烷基羰基或 CONH2。