(1,4-cyclohexyldiamine)(dihydrate)platinum(II) sulphate | 1610014-88-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (1,4-cyclohexyldiamine)(dihydrate)platinum(II) sulphate
• 英文别名: 1,4-cyclohexanediamine dihydrate platinum (II) sulphate
• CAS: 1610014-88-4
• 化学式: C₆H₁₈N₂O₂Pt*O₄S
• 分子量: 441.365
• InChiKey: NLTMMVTZZKNIJI-LIAJSWTCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  3'-(二氢磷酸)鸟嘌呤核苷 、 (1,4-cyclohexyldiamine)(dihydrate)platinum(II) sulphate 在 D₂SO₄ 作用下， 以 重水 为溶剂， 生成 Pt(cis-1,4-diaminocyclohexane)(3'-guanosine monophosphate)2
  参考文献：
  名称：

  Conformer Distribution in (cis-1,4-DACH)bis(guanosine-5′-phosphate)platinum(II) Adducts: A Reliable Model for DNA Adducts of Antitumoral Cisplatin

  摘要：

  In [PtCl2(CiS-1,4-DACH)] (DACH = diaminocyclohexane), the N-Pt-N bite angle (>= 97 degrees, as determined by X-ray diffraction analysis) is much larger than those found in other Pt complexes with bidentate diamines or in cisplatin (910). Hence, the possibility exists that in (cis-1,4-DACH)PtG(2) adducts, rotation of the G's around the Pt-N7 bonds is slowed enough to allow observation of different conformers. In accord with this prevision, decreasing the temperature to 238 K enabled us to observe different conformers of (cis-1,4-DACH)Pt(5'-GMP)2 (GMP = guanosine monophosphate). This observation is the first case in which such conformers for a platinum derivative with primary diamines and untethered guanines have been resolved and represents the closest model to clinically effective cisplatin obtained to date. We also found that the presence of the 1,4-DACH ligand increased the intensity of the circular dichroism signal stemming from the dominance of an HT conformer (Delta HT in the adduct with 3'-GMPs and Lambda HT in the adduct with 5'-GMPs).

  DOI：

  10.1021/ic702202x
• 作为产物：
  描述：

  1,4-环己烷二胺 以 水 为溶剂， 生成 (1,4-cyclohexyldiamine)(dihydrate)platinum(II) sulphate
  参考文献：
  名称：

  PLATINUM COMPOUND HAVING AMINO OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARTION METHOD THEREOF, AND USE THEREOF

  摘要：

  本发明揭示了一类铂化合物，其具有氨基或烷基氨基含有琥珀酸酯衍生物作为脱离基团，或其药用可接受的盐，以及其制备方法，以及含有这些化合物的药物组合物。本发明还揭示了这些化合物在治疗细胞增殖性疾病，特别是癌症方面的用途。本发明的铂化合物具有高水溶性和小毒副作用。

  公开号：

  US20140349985A1

文献信息

• PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASES, PREPARATION METHOD AND USE THEREOF
  申请人：Chen Xiaoping

  公开号：US20140142079A1

  公开（公告）日：2014-05-22

  Disclosed are a class of platinum compounds with a leaving group of malonic acid derivatives containing amino and alkylamino, their pharmaceutically acceptable salts, their preparation methods and pharmaceutical composites comprising them. Disclosed also are for the uses of the compounds in the treatment of cell proliferative diseases, particularly for the treatment of cancers. The present platinum compounds have high water solubility and low toxicity.

  本文披露了一类铂化合物，其离去基为含有氨基和烷基氨基的丙二酸衍生物，以及它们的药用可接受盐、制备方法和包括它们的药用组合物。本文还披露了这些化合物在治疗细胞增殖性疾病，特别是治疗癌症方面的用途。这些铂化合物具有高水溶性和低毒性。
• DNA fragment conformations in adducts with Kiteplatin
  作者：Nicola Margiotta、Emanuele Petruzzella、James A. Platts、Shaun T. Mutter、Robert J. Deeth、Rosa Ranaldo、Paride Papadia、Patricia A. Marzilli、Luigi G. Marzilli、James D. Hoeschele、Giovanni Natile

  DOI：10.1039/c4dt01796j

  日期：——

  The anticancer-active platinum complex with cis-1,4-diaminocyclohexane has proved to be very valuable in detecting multiple conformers in adducts with oligonucleotides.

  具有cis-1,4-二氨基环己烷的抗癌活性铂配合物已被证明在检测与寡核苷酸的加合物中的多个构象体方面非常有价值。
• PLATINUM COMPOUND HAVING AMINO- OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：Beijing Fswelcome Technology Development Co., Ltd

  公开号：EP2759547B1

  公开（公告）日：2017-01-18
• PLATINUM COMPOUNDS FOR TREATING CELL PROLIFERATIVE DISEASE, PREPARATION METHODS AND USES THEREOF
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT, CO., LTD

  公开号：EP2740738B1

  公开（公告）日：2018-03-28
• PLATINUM COMPOUND OF MALONIC ACID DERIVATIVE HAVING LEAVING GROUP CONTAINING AMINO OR ALKYLAMINO
  申请人：Beijing Shuobai Pharmaceutical Co., LTD

  公开号：EP2924044B1

  公开（公告）日：2018-10-31