N-[(E)-1-(6-nitro-1H-benzimidazol-2-yl)-2-phenylvinyl]benzamide | 1276667-43-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[(E)-1-(6-nitro-1H-benzimidazol-2-yl)-2-phenylvinyl]benzamide
• 英文别名: N-[(E)-1-(6-nitro-1H-benzimidazol-2-yl)-2-phenylethenyl]benzamide
• CAS: 1276667-43-6
• 化学式: C₂₂H₁₆N₄O₃
• 分子量: 384.394
• InChiKey: LCCZSRQVSUVAHS-DEDYPNTBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲醛 在 sodium acetate 、 乙酸酐 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 20.0h， 生成 N-[(E)-1-(6-nitro-1H-benzimidazol-2-yl)-2-phenylvinyl]benzamide
  参考文献：
  名称：

  Synthesis of (substituted benzamidostyryl) lH-benzimidazoles and their screening for anti-inflammatory activity

  摘要：

  A series of substituted (benzamidostyryl) benzimidazole (3a-r) were synthesized and evaluated for their possible anti-inflammatory and ulcerogenicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in carrageenan-induced hind paw edema method test and compounds 3b, 3k had shown high potency after 3 and 4 h time intervals (P < 0.001) almost equipotent to the standard drug indomethacin and showed less severity index than it.

  DOI：

  10.1007/s00044-011-9552-1